Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 2/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 5/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29507822 | 0.86 | CDK19 (0.43) | CDK2CDK9MAPK1MAP3K7MAP2K1 | |
| SCHEMBL24388679 | 0.86 | CDK19 (0.43) | CDK2CDK9MAPK1MAP3K7MAP2K1 | |
| SCHEMBL29508200 | 0.83 | CDK2 (0.51) | CCNT1CCNE2CCNE1CDK2CDK9 | |
| SCHEMBL29508118 | 0.81 | JAK3 (0.62) | MAPK1MAP3K7MAP2K1JAK3BTK | |
| SCHEMBL24388573 | 0.81 | JAK3 (0.62) | MAPK1MAP3K7MAP2K1JAK3BTK | |
| SCHEMBL29250611 | 0.78 | EGFR (0.53) | CCNT1CCNE2CCNE1CDK2CDK9 | |
| SCHEMBL29250612 | 0.78 | CDK2 (0.57) | CCNT1CCNE2CCNE1CDK2CDK9 | |
| SCHEMBL29507923 | 0.75 | CDK2 (0.49) | CCNT1CCNE2CCNE1CDK2CDK9 | |
| SCHEMBL16513405 | 0.75 | CDK19 (0.56) | CCNT1CCNE2CCNE1CDK2CDK9 | |
| SCHEMBL29508122 | 0.75 | CDK2 (0.48) | CCNT1CCNE2CCNE1CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237088-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | Blueprint Medicines Corporation (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022094355-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |