Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.51 |
| ▸ | CDK9 | P50750 | 4/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.45 |
| ▸ | CDK19 | Q9BWU1 | 4/20 | 0.45 |
| ▸ | JAK3 | P52333 | 6/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29250652 | 0.84 | CDK2 (0.52) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29508097 | 0.83 | CCNT1 (0.47) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29065172 | 0.82 | ALK (0.56) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29250611 | 0.78 | EGFR (0.53) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29250612 | 0.76 | CDK2 (0.57) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29065154 | 0.75 | ALK (0.68) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29508122 | 0.75 | CDK2 (0.48) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL16513405 | 0.75 | CDK19 (0.56) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29538295 | 0.73 | ALK (0.56) | CDK2CDK9CCNT1CCNE2CCNE1 | |
| SCHEMBL29250674 | 0.73 | ALK (0.56) | CDK2CDK9CCNT1CCNE2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4237088-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | Blueprint Medicines Corporation (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022094355-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |