Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 20/20 | 0.61 |
| ▸ | CDK2 | P24941 | 20/20 | 0.61 |
| ▸ | CCND1 | P24385 | 17/20 | 0.61 |
| ▸ | CDK6 | Q00534 | 17/20 | 0.61 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.60 |
| ▸ | CDK9 | P50750 | 5/20 | 0.60 |
| ▸ | CDK4 | P11802 | 4/20 | 0.60 |
| ▸ | RB1 | P06400 | 1/20 | 0.60 |
| ▸ | CDK1 | P06493 | 1/20 | 0.60 |
| ▸ | CCND3 | P30281 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22860648 | 0.89 | CCNE1 (0.68) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL29507786 | 0.89 | CCNE1 (0.68) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL29508843 | 0.87 | CCNE1 (0.71) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL22860359 | 0.87 | CCNE1 (0.71) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL22860262 | 0.86 | CCNE1 (0.64) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL22164779 | 0.85 | CCNE1 (0.76) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL29507753 | 0.85 | CCNE1 (0.76) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL29508789 | 0.85 | CCNE1 (0.61) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL22860258 | 0.85 | CCNE1 (0.61) | CCNE1CDK2CCND1CDK6CCNT1 | |
| SCHEMBL22860414 | 0.85 | CCNE1 (0.75) | CCNE1CDK2CCND1CDK6CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3993802-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Nuvation Bio Inc. (US) | 2022-05-11 | — | — | EP | disclosed |