Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23668773 | 1.00 | NOTUM (0.33) | NOTUMTSHRPOLB | |
| SCHEMBL29656521 | 0.82 | SIGMAR1 (0.41) | TSHR | |
| SCHEMBL23360888 | 0.82 | SIGMAR1 (0.41) | TSHR | |
| SCHEMBL23645253 | 0.82 | — | — | |
| SCHEMBL28795655 | 0.81 | PDK2 (0.33) | NOTUMTSHR | |
| SCHEMBL29732200 | 0.81 | PDK2 (0.33) | NOTUMTSHR | |
| SCHEMBL28795625 | 0.75 | HRH3 (0.37) | NOTUMTSHRPOLB | |
| SCHEMBL28795603 | 0.75 | HRH3 (0.37) | NOTUMTSHRPOLB | |
| SCHEMBL28795590 | 0.75 | HRH3 (0.37) | NOTUMTSHRPOLB | |
| SCHEMBL19279361 | 0.74 | AKR1C1 (0.38) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11312724-B2 | Spirocyclic tetrahydroquinazolines | ASCENTAGE PHARMA (SUZHOU) CO., LTD. | 2022-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11312724-B2 | Spirocyclic tetrahydroquinazolines | KRAS, NRAS, HRAS | NOTUM 4614/4885TSHR 3233/4885POLB 2644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.