Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28795655 | 1.00 | PDK2 (0.33) | PDK2KDM4EALDH1A1LMNATP53 | |
| SCHEMBL29732300 | 0.85 | PDK2 (0.40) | PDK2LMNA | |
| SCHEMBL28795605 | 0.85 | PDK2 (0.40) | PDK2LMNA | |
| SCHEMBL23668773 | 0.81 | NOTUM (0.33) | TSHRNOTUM | |
| SCHEMBL29509366 | 0.81 | NOTUM (0.33) | TSHRNOTUM | |
| SCHEMBL23360888 | 0.71 | SIGMAR1 (0.41) | ALDH1A1TP53TSHR | |
| SCHEMBL29656521 | 0.71 | SIGMAR1 (0.41) | ALDH1A1TP53TSHR | |
| SCHEMBL23645253 | 0.70 | — | — | |
| SCHEMBL29732180 | 0.70 | PDK2 (0.34) | PDK2TSHRSMN1; SMN2 | |
| SCHEMBL29732305 | 0.70 | PDK2 (0.34) | PDK2TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114805311-B | Spirocyclic indenes | 苏州亚盛药业有限公司 | 2024-10-29 | — | — | CN | disclosed |
| WO-2022156761-A1 | SPIROCYCLIC INDENES | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2022-07-28 | — | — | WO | disclosed |