Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | LOX | P28300 | 1/20 | 0.30 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24344995 | 0.89 | LRRK2 (0.35) | LRRK2MCHR1HTR1AADRA2AADRA2B | |
| SCHEMBL25344006 | 0.83 | LRRK2 (0.43) | LRRK2MCHR1S1PR1S1PR3PDE4A | |
| SCHEMBL29502046 | 0.72 | NOS2 (0.50) | — | |
| SCHEMBL24344996 | 0.71 | HCRTR1 (0.39) | LRRK2HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL29534763 | 0.70 | LRRK2 (0.35) | LRRK2HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL24344934 | 0.70 | LRRK2 (0.35) | LRRK2HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL3202404 | 0.69 | IKBKB (0.45) | ADRA2BHPGDSMN1; SMN2IKBKB | |
| SCHEMBL29513590 | 0.69 | IKBKB (0.45) | ADRA2BHPGDSMN1; SMN2IKBKB | |
| SCHEMBL29957854 | 0.69 | SCD (0.36) | MCHR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL29953312 | 0.66 | ROCK1 (0.36) | MCHR1HTR1AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076973-A1 | 7-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES | ENLIVEN THERAPEUTICS, INC. (US) | 2022-04-14 | — | — | WO | disclosed |