SCHEMBL29953312

SCHEMBL29953312

Nc1nccc(OC2CC2)c1C=O

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ROCK1 Q13464 3/20 0.36
POLB P06746 1/20 0.36
IDO1 P14902 1/20 0.33
KMO O15229 2/20 0.33
HCRTR1 O43613 1/20 0.32
HCRTR2 O43614 1/20 0.32
MCHR1 Q99705 3/20 0.32
HTR1A P08908 1/20 0.32
ADRA2A P08913 1/20 0.32
ADRA2B P18089 1/20 0.32
ADRA2C P18825 1/20 0.32
AR P10275 5/20 0.31
LOX P28300 1/20 0.31
LOXL2 Q9Y4K0 1/20 0.31
MKNK1 Q9BUB5 1/20 0.31
MKNK2 Q9HBH9 1/20 0.31
ROCK2 O75116 1/20 0.31
KCNH2 Q12809 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29951188 0.80 LOX (0.38) POLBIDO1HCRTR1HCRTR2HTR1A
SCHEMBL29955574 0.79 MKNK1 (0.38) IDO1KMOHCRTR1HCRTR2MKNK1
SCHEMBL29957854 0.77 SCD (0.36) ROCK1POLBIDO1KMOMCHR1
SCHEMBL29958426 0.77 KMO (0.41) POLBIDO1KMOHCRTR1HCRTR2
SCHEMBL29952864 0.77 POLB (0.36) ROCK1POLBIDO1KMOHCRTR1
SCHEMBL15335119 0.76 ERN1 (0.40)
SCHEMBL29955612 0.74 CCR1 (0.37) ROCK1POLBLOXLOXL2ROCK2
SCHEMBL29952128 0.73 MCHR1 (0.39) POLBMCHR1HTR1AADRA2AADRA2B
SCHEMBL22834838 0.72 LOX (0.38) ROCK1KMOMCHR1LOXLOXL2
SCHEMBL29954270 0.71 LOX (0.38) POLBIDO1KMOHTR1AADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed