Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22527929 | 1.00 | KDM4E (0.46) | KDM4ESMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL18068165 | 0.81 | KDM4E (0.47) | KDM4ESMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL19778605 | 0.80 | KDM4E (0.49) | KDM4ESMN1; SMN2ALDH1A1POLBL3MBTL1 | |
| SCHEMBL17979201 | 0.80 | KDM4E (0.46) | KDM4ESMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL17979136 | 0.80 | KDM4E (0.46) | KDM4ESMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL29536213 | 0.80 | KDM4E (0.46) | KDM4ESMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL17979256 | 0.76 | KDM4E (0.43) | KDM4ESMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL21199750 | 0.76 | PSMD14 (0.37) | KDM4ESMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL4650346 | 0.75 | TUBB4A (0.47) | KDM4ESMN1; SMN2ALDH1A1LMNAPOLB | |
| SCHEMBL22528095 | 0.73 | KDM4E (0.40) | KDM4ESMN1; SMN2ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114364670-B | Substituted benzyl-triazole compound for Cbl-b inhibition and further application thereof | 纽力克斯治疗公司 | 2025-06-13 | — | — | CN | disclosed |
| CN-114364667-B | 3-Substituted piperidines for Cbl-b inhibition and use of Cbl-b inhibitors in combination with cancer vaccines and/or oncolytic viruses | 紐力克斯治疗公司 | 2025-01-10 | — | — | CN | disclosed |
| CN-114206855-B | Cyanocyclobutyl compounds for Cbl-b inhibition and application thereof | 紐力克斯治疗公司 | 2024-11-26 | — | — | CN | disclosed |
| CN-114364670-A | Substituted benzyl-triazoles for Cbl-b inhibition and further uses thereof | 纽力克斯治疗公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-114364667-A | 3-substituted piperidines for Cbl-b inhibition and the use of Cbl-b inhibitors in combination with cancer vaccines and/or oncolytic viruses | 紐力克斯治疗公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-114206855-A | Cyanocyclobutyl compounds for Cbl-b inhibition and uses thereof | 紐力克斯治疗公司 | 2022-03-18 | — | — | CN | disclosed |