SCHEMBL29514819

SCHEMBL29514819

O=C(Cl)/C=C/c1cccnc1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.73
MAPT P10636 2/20 0.73
KDM4E B2RXH2 2/20 0.73
NPC1 O15118 2/20 0.73
JUN P05412 1/20 0.73
NFKB1 P19838 1/20 0.73
MAPK1 P28482 1/20 0.73
GPR55 Q9Y2T6 1/20 0.73
PFKFB3 Q16875 1/20 0.63
KMT2A Q03164 1/20 0.59
CYP1A1 P04798 8/20 0.57
CYP1A2 P05177 8/20 0.57
CYP1B1 Q16678 8/20 0.57
CYP3A4 P08684 5/20 0.57
CYP2D6 P10635 5/20 0.57
APAF1 O14727 1/20 0.56
POLB P06746 1/20 0.56
TDP1 Q9NUW8 1/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
USP2 O75604 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL485947 1.00 RAB9A (0.73) RAB9AMAPTKDM4ENPC1JUN
SCHEMBL485944 1.00 RAB9A (0.73) RAB9AMAPTKDM4ENPC1JUN
Hydrochloric Acid SCHEMBL31565691 0.98 RAB9A (0.71) RAB9AMAPTKDM4ENPC1JUN
Hydrochloric Acid SCHEMBL2679096 0.98 RAB9A (0.71) RAB9AMAPTKDM4ENPC1JUN
Hydrochloric Acid SCHEMBL2679094 0.98 RAB9A (0.71) RAB9AMAPTKDM4ENPC1JUN
SCHEMBL5598850 0.85 MAPT (1.00) RAB9AMAPTKDM4ENPC1JUN
SCHEMBL5598852 0.85 MAPT (1.00) RAB9AMAPTKDM4ENPC1JUN
SCHEMBL29416684 0.83 RAB9A (0.76) RAB9AMAPTKDM4ENPC1JUN
SCHEMBL334615 0.83 RAB9A (0.76) RAB9AMAPTKDM4ENPC1JUN
SCHEMBL334614 0.83 RAB9A (0.76) RAB9AMAPTKDM4ENPC1JUN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117586256-A Substituted heterocyclic compounds 首药控股(北京)股份有限公司 2024-02-23 CN disclosed
CN-112625025-B Pyridyl substituted quinoline derivative and its prepn and use 河南省医药科学研究院 2022-03-29 CN disclosed