Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.73 |
| ▸ | NPC1 | O15118 | 2/20 | 0.73 |
| ▸ | JUN | P05412 | 1/20 | 0.73 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.73 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | CYP1A1 | P04798 | 8/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.57 |
| ▸ | CYP1B1 | Q16678 | 8/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.57 |
| ▸ | APAF1 | O14727 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485944 | 1.00 | RAB9A (0.73) | RAB9AMAPTKDM4ENPC1JUN | |
| SCHEMBL29514819 | 1.00 | RAB9A (0.73) | RAB9AMAPTKDM4ENPC1JUN | |
| Hydrochloric Acid SCHEMBL31565691 | 0.98 | RAB9A (0.71) | RAB9AMAPTKDM4ENPC1JUN | |
| Hydrochloric Acid SCHEMBL2679096 | 0.98 | RAB9A (0.71) | RAB9AMAPTKDM4ENPC1JUN | |
| Hydrochloric Acid SCHEMBL2679094 | 0.98 | RAB9A (0.71) | RAB9AMAPTKDM4ENPC1JUN | |
| SCHEMBL5598850 | 0.85 | MAPT (1.00) | RAB9AMAPTKDM4ENPC1JUN | |
| SCHEMBL5598852 | 0.85 | MAPT (1.00) | RAB9AMAPTKDM4ENPC1JUN | |
| SCHEMBL29416684 | 0.83 | RAB9A (0.76) | RAB9AMAPTKDM4ENPC1JUN | |
| SCHEMBL334615 | 0.83 | RAB9A (0.76) | RAB9AMAPTKDM4ENPC1JUN | |
| SCHEMBL334614 | 0.83 | RAB9A (0.76) | RAB9AMAPTKDM4ENPC1JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717574-B | Novel compounds and compositions for the inhibition of nampt | 福马TM有限责任公司 | 2017-02-22 | — | — | CN | disclosed |
| US-9382267-B2 | Small molecule inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2016-07-05 | — | — | US | disclosed |
| US-20150322093-A1 | SMALL MOLECULE INHIBITORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | THE CURATORS OF THE UNIVERSITY OF MISSOURI | 2015-11-12 | — | — | US | disclosed |
| US-9169209-B2 | Compounds and compositions for the inhibition of NAMPT | FORMA TM, LLC (US) | 2015-10-27 | — | — | US | disclosed |
| US-20140275057-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Valo Health, LLC | 2014-09-18 | — | — | US | disclosed |
| US-8618159-B2 | Substituted N-phenyl-bipyrrolidine carboxamides and therapeutic use thereof | SANOFI (FR) | 2013-12-31 | — | — | US | disclosed |
| WO-2013082150-A1 | SMALL MOLECULE INHIBITORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2013-06-06 | — | — | WO | disclosed |
| WO-2012150952-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | FORMA TM, LLC (US) | 2012-11-08 | — | — | WO | disclosed |
| CN-101903339-B | Substituted N-phenyl-bipyrrolidine carboxamides and their therapeutic use | SANOFI AVENTIS | 2012-06-27 | — | — | CN | disclosed |
| US-20120053170-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS ANTICANCER DRUGS | SANOFI (FR) | 2012-03-01 | — | — | US | disclosed |
| EP-2212282-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-04 | — | — | EP | disclosed |
| US-20100173897-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-07-08 | — | — | US | disclosed |
| WO-2009052065-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |
| US-6177438-B1 | ANALGESICS, DIURETICS, ANTITUSSIVE AGENTS | TORAY INDUSTRIES, INC. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0846689-A1 | Benzimidazole compounds | PFIZER INC. (US) | 1998-06-10 | — | — | EP | disclosed |
| EP-0663401-A1 | MORPHINAN DERIVATIVE AND MEDICINAL USE | TORAY INDUSTRIES, INC. (JP) | 1995-07-19 | — | — | EP | disclosed |
| EP-0079049-B1 | NOVEL SUBSTITUTED ALKANOYLIMIDAZOL-2-ONE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-01 | — | — | EP | disclosed |
| US-4447619-A | CARDIOTONIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-05-08 | — | — | US | disclosed |
| US-4367236-A | CARDIOTONIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-01-04 | — | — | US | disclosed |
| US-4189484-A | Antihypertensive quinazoline derivatives | MITSUBISHI YUKA PHARMACEUTICAL CO., LTD. (JP) | 1980-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173897-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | HRH3, HRH4, CNR1 | RAB9A 3245/4885MAPT 1607/4885KDM4E 1155/4885 |
| US-20120053170-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS ANTICANCER DRUGS | NAMPT, NNT, NQO1 | RAB9A 1557/4885MAPT 2480/4885KDM4E 1950/4885 |
| US-20150322093-A1 | SMALL MOLECULE INHIBITORS OF NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE (NAMPT) | NAMPT, NAPRT, NNMT | RAB9A 1979/4885MAPT 702/4885KDM4E 2504/4885 |
| US-20140275057-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | NAMPT, NNMT, NAPRT | RAB9A 1511/4885MAPT 422/4885KDM4E 2168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.