Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 11/20 | 0.56 |
| ▸ | GRM5 | P41594 | 11/20 | 0.56 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15146264 | 1.00 | GRM1 (0.56) | GRM1GRM5PDK4PRMT5GPR119 | |
| SCHEMBL24265543 | 0.88 | GRM5 (0.52) | GRM1GRM5PRMT5 | |
| SCHEMBL29574203 | 0.88 | GRM5 (0.52) | GRM1GRM5PRMT5 | |
| SCHEMBL29555104 | 0.87 | PRMT5 (0.49) | GRM1GRM5PRMT5TNK2 | |
| SCHEMBL16291515 | 0.87 | PRMT5 (0.49) | GRM1GRM5PRMT5TNK2 | |
| SCHEMBL25952378 | 0.85 | GRM1 (0.48) | GRM1GRM5PDK4GPR119NAMPT | |
| SCHEMBL24946524 | 0.85 | GRM1 (0.46) | GRM1GRM5PDK4GPR119WNT3A | |
| SCHEMBL24329776 | 0.85 | GRM1 (0.58) | GRM1GRM5PDK4GPR119NAMPT | |
| SCHEMBL31288575 | 0.84 | GRM1 (0.57) | GRM1GRM5PDK4GPR119NAMPT | |
| SCHEMBL16422787 | 0.84 | GRM1 (0.57) | GRM1GRM5PDK4GPR119NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4317142-A1 | THIOPHENE GLP-1 RECEPTOR AGONIST AND USE THEREOF | Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. (CN) | 2024-02-07 | — | — | EP | disclosed |
| CN-116940561-A | Thiophene GLP-1 receptor agonist and application thereof | 杭州中美华东制药有限公司 | 2023-10-24 | — | — | CN | disclosed |
| CN-114478497-B | Arylalkyl acid GLP-1 receptor agonists and uses thereof | 杭州中美华东制药有限公司 | 2023-10-20 | — | — | CN | disclosed |
| EP-4227299-A1 | BENZIMIDAZOLONE GLP-1 RECEPTOR AGONIST AND USE THEREOF | Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. (CN) | 2023-08-16 | — | — | EP | disclosed |
| CN-116507326-A | Compounds as GLP-1R agonists | 拓臻制药公司 | 2023-07-28 | — | — | CN | disclosed |
| CN-116348464-A | Benzimidazolone GLP-1 receptor agonists and uses thereof | 杭州中美华东制药有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-114478497-A | Aryl alkyl acids GLP-1 receptor agonists and uses thereof | 杭州中美华东制药有限公司 | 2022-05-13 | — | — | CN | disclosed |
| US-20220089578-A1 | COMPOUNDS AS GLP-1R AGONISTS | TERNS PHARMACEUTICALS, INC. | 2022-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089578-A1 | COMPOUNDS AS GLP-1R AGONISTS | GLP1R, GIPR, GCGR | GRM1 152/4885GRM5 255/4885PDK4 1038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.