Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.49 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16291515 | 1.00 | PRMT5 (0.49) | PRMT5CDK9ALDH1A1SMN1; SMN2GRM5 | |
| SCHEMBL24265543 | 0.90 | GRM5 (0.52) | PRMT5ALDH1A1SMN1; SMN2GRM5MEN1 | |
| SCHEMBL29574203 | 0.90 | GRM5 (0.52) | PRMT5ALDH1A1SMN1; SMN2GRM5MEN1 | |
| SCHEMBL29518255 | 0.87 | GRM1 (0.56) | PRMT5GRM5GRM1TNK2 | |
| SCHEMBL15146264 | 0.87 | GRM1 (0.56) | PRMT5GRM5GRM1TNK2 | |
| SCHEMBL20280123 | 0.82 | GABRA5 (0.42) | PRMT5 | |
| SCHEMBL16422799 | 0.82 | GRM1 (0.41) | PRMT5ALDH1A1SMN1; SMN2GRM5MEN1 | |
| SCHEMBL16107429 | 0.82 | PIM1 (0.47) | PRMT5CDK9ALDH1A1SMN1; SMN2GRM5 | |
| SCHEMBL26914039 | 0.80 | GLP1R (0.49) | — | |
| SCHEMBL25169744 | 0.80 | PRMT5 (0.44) | PRMT5CDK9ALDH1A1SMN1; SMN2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022199458-A1 | THIOPHENE GLP-1 RECEPTOR AGONIST AND USE THEREOF | 杭州中美华东制药有限公司 | 2022-09-29 | — | — | WO | disclosed |
| WO-2022078152-A1 | BENZIMIDAZOLONE GLP-1 RECEPTOR AGONIST AND USE THEREOF | 杭州中美华东制药有限公司 | 2022-04-21 | — | — | WO | disclosed |