Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 5/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | FABP2 | P12104 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12186095 | 0.82 | LMNA (0.46) | LMNARECQLADRA2BCES2CES1 | |
| SCHEMBL11996557 | 0.81 | GRIA4 (0.43) | LMNAPDCD1CD274GRIA4MAPT | |
| SCHEMBL5907405 | 0.81 | LMNA (0.46) | LMNARECQLPDCD1CD274MAPT | |
| SCHEMBL29519413 | 0.81 | PTGS1 (0.41) | LMNARECQLPDCD1CD274GRIA4 | |
| SCHEMBL11332491 | 0.78 | SIGMAR1 (0.40) | MAPT | |
| SCHEMBL11464305 | 0.75 | LMNA (0.55) | LMNAGRIA4GRIA2MAPTPTGS1 | |
| SCHEMBL30931034 | 0.74 | DHODH (0.40) | LMNAGRIA4MAPTRAB9APTGS1 | |
| SCHEMBL14252877 | 0.74 | LMNA (0.39) | LMNARECQLKMT2AADRA2BHTT | |
| SCHEMBL1327147 | 0.74 | LMNA (0.39) | LMNARECQLKMT2AADRA2BHTT | |
| SCHEMBL12124852 | 0.74 | LMNA (0.39) | LMNARECQLKMT2AADRA2BHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109743875-B | Inhibitors of the MENIN-MLL interaction | 生命医药有限责任公司 | 2022-04-29 | — | — | CN | disclosed |