Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.52 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.38 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.37 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.37 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.36 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.35 |
| ▸ | MAT2A | P31153 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29037887 | 1.00 | DYRK1A (0.52) | DYRK1ACDK9PRKCITGFBR1TGFBR2 | |
| SCHEMBL29037718 | 0.89 | NPC1 (0.41) | DYRK1ACDK9TGFBR1TGFBR2BTK | |
| SCHEMBL29520533 | 0.89 | NPC1 (0.41) | DYRK1ACDK9TGFBR1TGFBR2BTK | |
| SCHEMBL29520547 | 0.81 | CDK9 (0.41) | CDK9TGFBR1TGFBR2MAP3K20BTK | |
| SCHEMBL29037820 | 0.81 | CDK9 (0.41) | CDK9TGFBR1TGFBR2MAP3K20BTK | |
| SCHEMBL29520361 | 0.77 | TGFBR1 (0.40) | DYRK1ATGFBR1TGFBR2NPC1RAB9A | |
| SCHEMBL16042386 | 0.77 | CDK9 (0.56) | DYRK1ACDK9PRKCI | |
| SCHEMBL29037727 | 0.76 | LRRK2 (0.46) | CDK9PRKCITGFBR1BTKRPS6KA5 | |
| SCHEMBL29520550 | 0.76 | DYRK1A (0.44) | DYRK1ACDK9TGFBR1TGFBR2NPC1 | |
| SCHEMBL29520298 | 0.76 | NPC1 (0.39) | DYRK1ATGFBR1TGFBR2RPS6KA5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |