Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC1 | P07992 | 1/20 | 0.49 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 2/20 | 0.39 |
| ▸ | CDK8 | P49336 | 2/20 | 0.39 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | FASN | P49327 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21016920 | 1.00 | ERCC1 (0.49) | ERCC1ERCC4SLC2A1IRAK4SYK | |
| SCHEMBL21871231 | 0.89 | TRPA1 (0.45) | SLC2A1SYKCCNCCDK8TRPM5 | |
| SCHEMBL30039116 | 0.82 | IRAK4 (0.41) | IRAK4KMO | |
| SCHEMBL19836551 | 0.82 | IRAK4 (0.41) | IRAK4KMO | |
| SCHEMBL21016921 | 0.81 | KMO (0.44) | SLC2A1IRAK4KMO | |
| SCHEMBL15344155 | 0.79 | IRAK4 (0.48) | ERCC1ERCC4SLC2A1IRAK4SYK | |
| SCHEMBL21016916 | 0.79 | PTGER3 (0.39) | SLC2A1IRAK4KMO | |
| SCHEMBL29445974 | 0.78 | ERCC1 (0.47) | ERCC1ERCC4SLC2A1IRAK4SYK | |
| SCHEMBL17059337 | 0.77 | APP (0.49) | SLC2A1KMO | |
| SCHEMBL18652286 | 0.77 | IRAK4 (0.61) | ERCC1ERCC4SLC2A1IRAK4SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |