Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 10/20 | 0.42 |
| ▸ | SIK1 | P57059 | 2/20 | 0.41 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.41 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.41 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29520363 | 0.88 | PAK1 (0.42) | PAK1SIK1SIK2SIK3PKMYT1 | |
| SCHEMBL29520343 | 0.84 | PAK1 (0.45) | PAK1SIK1SIK2SIK3PKMYT1 | |
| SCHEMBL29037731 | 0.80 | WEE1 (0.49) | PAK1SIK1SIK2SIK3JAK3 | |
| SCHEMBL29037854 | 0.79 | EGFR (0.55) | PAK1PKMYT1EGFRFGFR1FGFR4 | |
| SCHEMBL29037768 | 0.78 | MAPK8 (0.51) | JAK3BTKCDK1CDK4CCNB1 | |
| SCHEMBL29520529 | 0.78 | PKMYT1 (0.44) | PAK1PKMYT1EGFRTNIK | |
| SCHEMBL29037832 | 0.78 | EGFR (0.51) | PAK1PKMYT1EGFRTNIK | |
| SCHEMBL29037758 | 0.77 | PAK1 (0.48) | PAK1SIK1SIK2SIK3EGFR | |
| SCHEMBL29037755 | 0.77 | SIK1 (0.52) | PAK1SIK1SIK2SIK3EGFR | |
| SCHEMBL29037869 | 0.76 | ALK (0.48) | FGFR1CDK1CDK4CCND1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |