Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31211967 | 0.91 | NPC1 (0.48) | NPC1ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL30771170 | 0.89 | NPC1 (0.45) | NPC1ALDH1A1MEN1KMT2AAPEX1 | |
| SCHEMBL27154315 | 0.82 | NPC1 (0.44) | NPC1ALDH1A1MEN1KMT2AGAA | |
| SCHEMBL24721138 | 0.81 | NPC1 (0.41) | NPC1EGFRIGF1RSRCFLT4 | |
| SCHEMBL30804530 | 0.80 | TSHR (0.55) | NPC1ALDH1A1L3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL32659833 | 0.80 | NPC1 (0.45) | NPC1EGFRIGF1RSRCFLT4 | |
| SCHEMBL638070 | 0.80 | NPC1 (0.45) | NPC1ALDH1A1MEN1KMT2AAPEX1 | |
| SCHEMBL28654976 | 0.79 | TSHR (0.56) | NPC1ALDH1A1GAAL3MBTL1RAB9A | |
| SCHEMBL30791436 | 0.79 | CYP1A2 (0.55) | NPC1ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL28612656 | 0.78 | KDM4E (0.54) | NPC1ALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |