Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 13/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | CCNK | O75909 | 1/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29037802 | 1.00 | BTK (0.53) | BTKBRD4ALKCDK2IGF1R | |
| SCHEMBL29037700 | 0.79 | BTK (0.58) | BTKBRD4ALKCDK2IGF1R | |
| SCHEMBL29520142 | 0.77 | PDGFRA (0.68) | BTKBRD4ALKCDK2IGF1R | |
| SCHEMBL29037693 | 0.77 | MAP4K1 (0.60) | BTKBRD4ALKCDK2IGF1R | |
| SCHEMBL29037816 | 0.77 | PDGFRA (0.68) | BTKBRD4ALKCDK2IGF1R | |
| SCHEMBL29520186 | 0.75 | BRD4 (0.37) | BTKBRD4 | |
| SCHEMBL29037889 | 0.75 | BRD4 (0.37) | BTKBRD4 | |
| SCHEMBL29037698 | 0.74 | BTK (0.59) | BTKBRD4ALKCDK2IGF1R | |
| SCHEMBL29037830 | 0.74 | BTK (0.57) | BTKBRD4ALKCDK2IGF1R | |
| SCHEMBL23409133 | 0.73 | ALK (0.72) | BTKBRD4ALKCDK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |