Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.37 |
| ▸ | KMO | O15229 | 4/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.33 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29037889 | 1.00 | BRD4 (0.37) | BRD4KMOHTR2AHTR2CHTR2B | |
| SCHEMBL29037802 | 0.75 | BTK (0.53) | BRD4BTK | |
| SCHEMBL29520591 | 0.75 | BTK (0.53) | BRD4BTK | |
| SCHEMBL29037804 | 0.70 | KMO (0.55) | KMOHTR2AHTR2CHTR2B | |
| SCHEMBL3980684 | 0.70 | HTR2A (0.47) | KMOHTR2AHTR2CHTR2B | |
| SCHEMBL29520376 | 0.70 | KMO (0.55) | KMOHTR2AHTR2CHTR2B | |
| SCHEMBL29520539 | 0.69 | PDE5A (0.39) | — | |
| SCHEMBL29520156 | 0.68 | DYRK1A (0.52) | BTKSLC16A3SLC16A1 | |
| SCHEMBL29037887 | 0.68 | DYRK1A (0.52) | BTKSLC16A3SLC16A1 | |
| SCHEMBL7539390 | 0.67 | AHR (0.48) | KMOBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |