Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 7/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 3/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29520343 | 0.80 | PAK1 (0.45) | EGFRBRD4JAK3PAK1 | |
| SCHEMBL29037767 | 0.73 | SIK1 (0.62) | EGFRAXLBRD4JAK3PAK1 | |
| SCHEMBL29037749 | 0.72 | ALK (0.69) | EGFRBRD4CCND3CDK9CDK6 | |
| SCHEMBL29520446 | 0.70 | KDM4E (0.41) | AXLBRD4 | |
| SCHEMBL29037876 | 0.70 | EGFR (0.60) | EGFRJAK3FLT3JAK1 | |
| SCHEMBL29037857 | 0.68 | EGFR (0.64) | EGFRJAK3FLT3JAK1 | |
| SCHEMBL29037894 | 0.68 | PAK1 (0.61) | EGFRBRD4PAK1 | |
| SCHEMBL29520433 | 0.68 | WEE1 (0.52) | EGFRAXLBRD4JAK3PAK1 | |
| SCHEMBL31684746 | 0.67 | JAK3 (0.71) | EGFRBRD4JAK3BTKFLT3 | |
| SCHEMBL29037725 | 0.66 | ALK (0.57) | EGFRBRD4JAK3JAK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |