Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPY2R | P49146 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29520120 | 0.80 | KDM4E (0.60) | KDM4EL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29037680 | 0.80 | KDM4E (0.60) | KDM4EL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29520501 | 0.77 | MAPT (0.51) | KDM4EL3MBTL1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL29520409 | 0.74 | ALDH1A1 (0.57) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL29520312 | 0.72 | KDM4E (0.48) | KDM4EL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29037795 | 0.72 | KDM4E (0.48) | KDM4EL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29520808 | 0.70 | EGFR (0.48) | AXLBRD4 | |
| SCHEMBL5743284 | 0.67 | KDM4E (0.56) | KDM4EL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23375915 | 0.65 | ALDH1A1 (0.41) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL29037742 | 0.64 | CCNA2 (0.50) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |