SCHEMBL29522503

SCHEMBL29522503

N=C1OC(=N)c2ccccc21

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.45
ALOX15 P16050 1/20 0.45
S100A4 P26447 2/20 0.38
MEN1 O00255 4/20 0.35
KMT2A Q03164 4/20 0.35
CDC25B P30305 2/20 0.35
MAPK1 P28482 4/20 0.33
ALDH1A1 P00352 4/20 0.33
KDM4E B2RXH2 3/20 0.33
L3MBTL1 Q9Y468 3/20 0.33
POLB P06746 2/20 0.33
NPC1 O15118 2/20 0.33
MAOA P21397 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
CES2 O00748 1/20 0.33
APAF1 O14727 1/20 0.33
TERT O14746 1/20 0.33
PLIN1 O60240 1/20 0.33
TDP2 O95551 1/20 0.33
S1PR4 O95977 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL153656 1.00 TDP1 (0.45) TDP1ALOX15S100A4MEN1KMT2A
Hydrochloric Acid SCHEMBL584695 0.97 ALOX15 (0.43) TDP1ALOX15S100A4MEN1KMT2A
SCHEMBL30447948 0.83 TDP1 (0.65) TDP1ALOX15S100A4MEN1KMT2A
SCHEMBL266796 0.83 TDP1 (0.65) TDP1ALOX15S100A4MEN1KMT2A
SCHEMBL29481018 0.67 S100A4 (0.58) TDP1ALOX15S100A4MEN1KMT2A
SCHEMBL5712107 0.67 S100A4 (0.58) TDP1ALOX15S100A4MEN1KMT2A
SCHEMBL16385020 0.66 KDM4E (0.38) TDP1ALOX15MAPK1KDM4EMAOA
SCHEMBL3141116 0.65 S100A4 (0.63) TDP1ALOX15S100A4MEN1KMT2A
SCHEMBL933891 0.65 S100A4 (0.63) TDP1ALOX15S100A4MEN1KMT2A
SCHEMBL11875421 0.64 MEN1 (0.61) TDP1ALOX15S100A4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4735049-A1 BIOACTIVE CONJUGATES, PREPARATION METHOD AND USE THEREOF Beone Medicines I GmbH (CH) 2026-05-06 EP disclosed
EP-4735048-A1 BIOACTIVE CONJUGATES, PREPARATION METHOD AND USE THEREOF Beone Medicines I GmbH (CH) 2026-05-06 EP disclosed
EP-4683672-A1 BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF Beone Medicines I GmbH (CH) 2026-01-28 EP disclosed
EP-4661913-A1 SELF-STABILIZING LINKER CONJUGATES Beone Medicines I GmbH (CH) 2025-12-17 EP disclosed
EP-4642490-A1 B7H3 ANTIBODY DRUG CONJUGATES Beone Medicines I GmbH (CH) 2025-11-05 EP disclosed
EP-4594327-A1 LIGAND-DRUG CONJUGATE OF EXATECAN ANALOGUE, AND MEDICAL USE THEREOF BeiGene Switzerland GmbH (CH) 2025-08-06 EP disclosed
WO-2025124456-A1 ANTIBODY DRUG CONJUGATE PLATFORMS BEIGENE, LTD. (KY) 2025-06-19 WO disclosed
CN-119948031-A Ligand-drug conjugates of isatecan analogs and medical uses thereof 广州百济神州生物制药有限公司 2025-05-06 CN disclosed
EP-4536666-A1 ANTIBODY DRUG CONJUGATES BeiGene, Ltd. (KY) 2025-04-16 EP disclosed
WO-2025032555-A1 BIOACTIVE CONJUGATES, PREPARATION METHOD AND USE THEREOF BEIGENE SWITZERLAND GMBH (CH) 2025-02-13 WO disclosed
WO-2025032556-A1 BIOACTIVE CONJUGATES, PREPARATION METHOD AND USE THEREOF BEIGENE SWITZERLAND GMBH (CH) 2025-02-13 WO disclosed
CN-119317630-A Antibody drug conjugates 百济神州有限公司 2025-01-14 CN disclosed
WO-2025002368-A1 BIOACTIVE CONJUGATES, PREPARATION METHOD AND USE THEREOF BEIGENE, LTD. (GB) 2025-01-02 WO disclosed
WO-2025002370-A1 BIOACTIVE CONJUGATES, PREPARATION METHOD AND USE THEREOF BEIGENE, LTD. (GB) 2025-01-02 WO disclosed
WO-2024194851-A1 BIOACTIVE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF BEIGENE SWITZERLAND GMBH (CH) 2024-09-26 WO disclosed
WO-2024165045-A1 SELF-STABILIZING LINKER CONJUGATES BEIGENE, LTD. (KY) 2024-08-15 WO disclosed
CN-118450907-A Antibody drug conjugates 百济神州有限公司 2024-08-06 CN disclosed
WO-2024067811-A1 LIGAND-DRUG CONJUGATE OF EXATECAN ANALOGUE, AND MEDICAL USE THEREOF BEIGENE, LTD. (KY) 2024-04-04 WO disclosed
WO-2023237050-A1 ANTIBODY DRUG CONJUGATES BEIGENE, LTD. (KY) 2023-12-14 WO disclosed
CN-106117213-B Heteroaryl compounds and methods for their synthesis and purification 西格诺药品有限公司 2022-03-18 CN disclosed