Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1841951 | 1.00 | KDM4E (0.47) | KDM4EHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL22902580 | 0.88 | IKBKB (0.53) | KDM4EHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL17840873 | 0.85 | KDM4E (0.44) | KDM4EHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL30641332 | 0.85 | KDM4E (0.44) | KDM4EHSD17B10ALDH1A1MEN1KMT2A | |
| SCHEMBL1579279 | 0.84 | ALDH1A1 (0.47) | KDM4EHSD17B10ALDH1A1MAPK1TSHR | |
| SCHEMBL30416311 | 0.84 | ALDH1A1 (0.47) | KDM4EHSD17B10ALDH1A1MAPK1TSHR | |
| SCHEMBL29678780 | 0.82 | KDM4E (0.53) | KDM4EHSD17B10ALDH1A1ACHEGAA | |
| SCHEMBL110643 | 0.82 | KDM4E (0.53) | KDM4EHSD17B10ALDH1A1ACHEGAA | |
| SCHEMBL1578944 | 0.79 | CYP4F2 (0.50) | KDM4EALDH1A1MAPK1TSHRCASP1 | |
| SCHEMBL31138796 | 0.79 | CYP4F2 (0.50) | KDM4EALDH1A1MAPK1TSHRCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114423757-B | Tricyclic heteroaryl compounds useful as IRAK4 inhibitors | 百时美施贵宝公司 | 2024-07-02 | — | — | CN | disclosed |
| EP-3999508-A1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS IRAK4 INHIBITORS | Bristol-Myers Squibb Company (US) | 2022-05-25 | — | — | EP | disclosed |
| CN-114423757-A | Tricyclic heteroaryl compounds useful as IRAK4 inhibitors | 百时美施贵宝公司 | 2022-04-29 | — | — | CN | disclosed |