Hederagenin

Hederagenin

SCHEMBL29523111

CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@]43C)[C@H]2C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 10/20 1.00
F3 P13726 4/20 1.00
USP7 Q93009 3/20 1.00
USP2 O75604 2/20 1.00
LMNA P02545 1/20 1.00
CYP3A4 P08684 1/20 1.00
SLCO1B3 Q9NPD5 1/20 1.00
SLCO1B1 Q9Y6L6 1/20 1.00
ALOX5 P09917 2/20 0.80
POLB P06746 3/20 0.79
PTPN2 P17706 3/20 0.79
CES1 P23141 3/20 0.79
PSMB11 A5LHX3 2/20 0.79
PSMA7 O14818 2/20 0.79
AKR1B10 O60218 2/20 0.79
PLA2G1B P04054 2/20 0.79
PTPRC P08575 2/20 0.79
PTPRF P10586 2/20 0.79
PSMB1 P20618 2/20 0.79
ACP1 P24666 2/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hederagenin SCHEMBL18818579 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL359809 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL13395362 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL15382983 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL12968366 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL18704478 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL12919815 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL18293409 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL21892153 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL14132125 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119318661-A Pharmaceutical composition for treating TDP-43 protein diseases, and preparation method and application thereof 中国科学院生物物理研究所 2025-01-17 CN claimed
CN-119074788-A Hedera helix extract and preparation method and application thereof 浙江康恩贝中药有限公司 2024-12-06 CN claimed
CN-119074745-A Hedera helix saponin composition, hedera helix leaf extract comprising the composition and application thereof 浙江康恩贝中药有限公司 2024-12-06 CN claimed
CN-118948913-A Composition of hedera helix leaf extract and yeast beta glucan and application thereof 南京北极光生物科技有限公司 2024-11-15 CN claimed
CN-118286240-A Application of active compound separated from clematis terniflora serving as pancreatic lipase inhibitor in preparation of weight-losing and lipid-lowering medicines 河西学院 2024-07-05 CN claimed
CN-114796293-B Application of hederagenin C 苏州大学 2024-06-11 CN claimed
CN-117205134-A Oil-control hair washing agent and preparation method thereof 浙江养丝生物医药科技有限公司 2023-12-12 CN claimed
CN-115260274-B Method for preparing hederagenin C from clematis tangutica 大连工业大学 2023-07-25 CN claimed
CN-114805466-B Preparation method of hedera helix extract 湖南朗林生物资源股份有限公司 2023-06-20 CN claimed
CN-114213501-B C-23 nitrogen-containing heterocyclic derivative of cycloisoxazole ring hederagenin and preparation method thereof 烟台大学 2023-01-20 CN claimed
CN-115260274-A Method for preparing hederagenin C from clematis tangutica 大连工业大学 2022-11-01 CN claimed
CN-114796293-A Application of hederagenin C 苏州大学 2022-07-29 CN claimed
CN-114213501-A C-23 nitrogen-containing heterocyclic derivative of A-ring-fused isoxazole ring hederagenin and preparation method thereof 烟台大学 2022-03-22 CN claimed
CN-121449674-A Hedera helix sapogenin C-2-site heterocyclic oxime ester derivative, and preparation method and application thereof 烟台大学 2026-02-03 CN disclosed
CN-120923572-A Hederaoside C deglycosylated derivative and preparation method and application thereof 苏州大学 2025-11-11 CN disclosed
CN-120643583-A Application of hederagenin C and deglycosylated derivative thereof in preparation of drugs or skin care products for repairing UV (ultraviolet) damage 苏州大学 2025-09-16 CN disclosed
CN-114796293-A Application of hederagenin C 苏州大学 2022-07-29 CN disclosed
CN-114796293-A Application of hederagenin C 苏州大学 2022-07-29 CN disclosed
CN-114213501-A C-23 nitrogen-containing heterocyclic derivative of A-ring-fused isoxazole ring hederagenin and preparation method thereof 烟台大学 2022-03-22 CN disclosed
CN-114191439-A Application of C-23 nitrogen-containing heterocyclic derivative of cycloisoxazole ring hederagenin A 烟台大学 2022-03-18 CN disclosed