Hederagenin

Hederagenin

SCHEMBL359809

CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)[C@@](C)(CO)[C@@H]5CC[C@]43C)[C@@H]2C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 10/20 1.00
F3 P13726 4/20 1.00
USP7 Q93009 3/20 1.00
USP2 O75604 2/20 1.00
LMNA P02545 1/20 1.00
CYP3A4 P08684 1/20 1.00
SLCO1B3 Q9NPD5 1/20 1.00
SLCO1B1 Q9Y6L6 1/20 1.00
ALOX5 P09917 2/20 0.80
POLB P06746 3/20 0.79
PTPN2 P17706 3/20 0.79
CES1 P23141 3/20 0.79
PSMB11 A5LHX3 2/20 0.79
PSMA7 O14818 2/20 0.79
AKR1B10 O60218 2/20 0.79
PLA2G1B P04054 2/20 0.79
PTPRC P08575 2/20 0.79
PTPRF P10586 2/20 0.79
PSMB1 P20618 2/20 0.79
ACP1 P24666 2/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hederagenin SCHEMBL18818579 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL13395362 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL29523111 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL15382983 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL12968366 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL18704478 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL12919815 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL18293409 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL21892153 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA
Hederagenin SCHEMBL14132125 1.00 PTPN1 (1.00) PTPN1F3USP7USP2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2535 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12617746-B2 Method of preparing triterpenoid compound NATIONAL TAIWAN UNIVERSITY (TW) 2026-05-05 US claimed
CN-121574172-A Hederagenin C-23 heterocyclic ester derivative, and preparation method and application thereof 烟台大学 2026-02-27 CN claimed
CN-121569845-A Application of saponin in inhibiting penicillium 内蒙古清源保生物科技有限公司 2026-02-27 CN claimed
US-20260053768-A1 Sustained Nitric Oxide Releasing Drug Delivery Systems HADAYA MAHER (US) 2026-02-26 US claimed
EP-3731833-B1 COMPOSITIONS CONTAINING THYMOHYDROQUINONE AND THEIR METHOD OF PREPARATION SAMI SABINSA GROUP LTD (IN) 2025-12-10 EP claimed
US-20250352445-A1 COMPOSITIONS FOR SEBUM CONTROL DYSON OPERATIONS PTE LTD (SG) 2025-11-20 US claimed
WO-2025235336-A1 SUSTAINED NITRIC OXIDE RELEASING DRUG DELIVERY SYSTEMS HADAYA MAHER (US) 2025-11-13 WO claimed
US-20250338841-A1 Dry Powdered Compositions and Methods and Uses Thereof NEOZYME INTERNATIONAL, INC. (US) 2025-11-06 US claimed
WO-2025215232-A1 A COMPOSITION COMPRISING A SAPONIN AND/OR AN ANTHELMINTIC AND/OR A MITOCHONDRIAL UNCOUPLER FOR THE TREATMENT OF LIVER DISEASE RAINCASTLE BIO. LIMITED (GB) 2025-10-16 WO claimed
US-20250295800-A1 CONJUGATE OF A SINGLE DOMAIN ANTIBODY, A SAPONIN AND AN EFFECTOR MOLECULE, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, THERAPEUTIC USE OF SAID PHARMACEUTICAL COMPOSITION SAPREME TECH BV (NL) 2025-09-25 US claimed
CN-1137748-A Gas used as local and subcutaneous transmission carrier and microspheres filled with gas precursor IMARX PHARMACEUTICAL CORP (US) 1996-12-11 CN claimed
EP-0740528-A1 GAS MICROSPHERES FOR TOPICAL AND SUBCUTANEOUS APPLICATION IMARX PHARMACEUTICAL CORP. (US) 1996-11-06 EP claimed
WO-1995032006-A1 GAS FILLED MICROSPHERES AS COMPUTED TOMOGRAPHY CONTRAST AGENTS IMARX, PHARMACEUTICAL CORP. (US) 1995-11-30 WO claimed
WO-1995024184-A1 GAS FILLED MICROSPHERES AS MAGNETIC RESONANCE IMAGING CONTRAST AGENTS UNGER EVAN C (US) 1995-09-14 WO claimed
EP-0555484-B1 WATER-SOLUBLE PENTACYCLIC TRITERPENE COMPOSITION AND PRODUCTION THEREOF HOKKAIDOSUGAR CO LTD (JP) 1995-09-06 EP claimed
WO-1995015118-A1 GAS MICROSPHERES FOR TOPICAL AND SUBCUTANEOUS APPLICATION IMARX PHARMACEUTICAL CORP. (US) 1995-06-08 WO claimed
EP-0558509-B1 USE OF MEDICAGO SAPONINS FOR THE PREPARATION OF COSMETIC OR PHARMACEUTICAL COMPOSITIONS, DERMATOLOGICAL COMPOSITIONS IN PARTICULAR, HELPING RENEW THE EPIDERMIS, STIMULATING REGROWTH OF HAIR, OR DELAYING HAIR LOSS LVMH RECH (FR) 1995-03-15 EP claimed
US-5314877-A Water-soluble pentacyclic triterpene composition and method for producing the same HOKKAIDO SUGAR CO., LTD. (JP) 1994-05-24 US claimed
EP-0555484-A1 WATER-SOLUBLE PENTACYCLIC TRITERPENE COMPOSITION AND PRODUCTION THEREOF HOKKAIDOSUGAR CO., LTD. (JP) 1993-08-18 EP claimed
US-4606911-A PENTACYCLIC ACID TRITERPENES ROHTO PHARMACEUTICAL CO. LTD. (JP) 1986-08-19 US claimed