Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 19/20 | 1.00 |
| ▸ | RIPK3 | Q9Y572 | 18/20 | 1.00 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.65 |
| ▸ | IKBKB | O14920 | 1/20 | 0.65 |
| ▸ | RAF1 | P04049 | 1/20 | 0.65 |
| ▸ | PDGFA | P04085 | 1/20 | 0.65 |
| ▸ | CDK1 | P06493 | 1/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.65 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.65 |
| ▸ | BRAF | P15056 | 1/20 | 0.65 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.65 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.65 |
| ▸ | CDK2 | P24941 | 1/20 | 0.65 |
| ▸ | KDR | P35968 | 1/20 | 0.65 |
| ▸ | GSK3B | P49841 | 1/20 | 0.65 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.65 |
| ▸ | TEK | Q02763 | 1/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25412537 | 0.87 | RIPK1 (1.00) | RIPK1RIPK3CHEK1IKBKBRAF1 | |
| SCHEMBL30358255 | 0.87 | RIPK1 (1.00) | RIPK1RIPK3CHEK1IKBKBRAF1 | |
| SCHEMBL29525067 | 0.84 | RIPK3 (1.00) | RIPK1RIPK3 | |
| SCHEMBL29025422 | 0.83 | RIPK1 (0.93) | RIPK1RIPK3CHEK1IKBKBRAF1 | |
| SCHEMBL29525630 | 0.83 | RIPK1 (1.00) | RIPK1RIPK3 | |
| SCHEMBL29525811 | 0.83 | RIPK3 (0.87) | RIPK1RIPK3CHEK1IKBKBRAF1 | |
| SCHEMBL29525367 | 0.80 | BRAF (0.83) | RIPK1RIPK3CHEK1IKBKBRAF1 | |
| SCHEMBL823682 | 0.79 | BRAF (1.00) | RIPK1RIPK3CHEK1IKBKBRAF1 | |
| SCHEMBL29525426 | 0.79 | RIPK3 (0.86) | RIPK1RIPK3 | |
| SCHEMBL2453182 | 0.76 | RIPK1 (0.80) | RIPK1RIPK3CHEK1IKBKBRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053630-B | Benzothiazole derivative and application thereof | 中国人民解放军第二军医大学 | 2022-04-01 | — | — | CN | disclosed |