Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 19/20 | 1.00 |
| ▸ | RIPK3 | Q9Y572 | 17/20 | 1.00 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.74 |
| ▸ | IKBKB | O14920 | 1/20 | 0.74 |
| ▸ | RAF1 | P04049 | 1/20 | 0.74 |
| ▸ | PDGFA | P04085 | 1/20 | 0.74 |
| ▸ | CDK1 | P06493 | 1/20 | 0.74 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.74 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.74 |
| ▸ | BRAF | P15056 | 1/20 | 0.74 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.74 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.74 |
| ▸ | CDK2 | P24941 | 1/20 | 0.74 |
| ▸ | KDR | P35968 | 1/20 | 0.74 |
| ▸ | GSK3B | P49841 | 1/20 | 0.74 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.74 |
| ▸ | TEK | Q02763 | 1/20 | 0.74 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.74 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25412537 | 1.00 | RIPK1 (1.00) | RIPK1RIPK3CHEK1IKBKBRAF1 | |
| SCHEMBL29025422 | 0.96 | RIPK1 (0.93) | RIPK1RIPK3CHEK1IKBKBRAF1 | |
| SCHEMBL29525811 | 0.93 | RIPK3 (0.87) | RIPK1RIPK3CHEK1IKBKBRAF1 | |
| SCHEMBL29025431 | 0.89 | RIPK1 (0.94) | RIPK1RIPK3CHEK1IKBKBRAF1 | |
| SCHEMBL2453182 | 0.89 | RIPK1 (0.80) | RIPK1RIPK3CHEK1IKBKBRAF1 | |
| SCHEMBL22275546 | 0.88 | RIPK1 (0.82) | RIPK1RIPK3CHEK1IKBKBRAF1 | |
| SCHEMBL823638 | 0.87 | RIPK1 (0.81) | RIPK1RIPK3CHEK1IKBKBRAF1 | |
| SCHEMBL28496454 | 0.87 | RIPK1 (0.81) | RIPK1RIPK3CHEK1IKBKBRAF1 | |
| SCHEMBL29525629 | 0.87 | RIPK1 (1.00) | RIPK1RIPK3CHEK1IKBKBRAF1 | |
| SCHEMBL29025446 | 0.86 | RIPK1 (0.88) | RIPK1RIPK3CHEK1IKBKBRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230277538-A1 | THERAPEUTICS FOR THE TREATMENT OF FSHD | UCL BUSINESS LTD (GB) | 2023-09-07 | — | — | US | claimed |
| EP-4171534-A1 | THERAPEUTICS FOR THE TREATMENT OF FSHD | UCL Business Ltd (GB) | 2023-05-03 | — | — | EP | claimed |
| WO-2024197097-A2 | COMPOSITIONS AND METHODS UTILIZING NOVEL MECHANISMS TARGETING CELL RESPONSES TO STRESS | NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY (US) | 2024-09-26 | — | — | WO | disclosed |
| US-20230277538-A1 | THERAPEUTICS FOR THE TREATMENT OF FSHD | UCL BUSINESS LTD (GB) | 2023-09-07 | — | — | US | disclosed |