Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | HTR2C | P28335 | 5/20 | 0.49 |
| ▸ | HTR2B | P41595 | 5/20 | 0.49 |
| ▸ | KCNN2 | Q9H2S1 | 4/20 | 0.49 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.49 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18192351 | 0.82 | MAOA (0.62) | MAOAKCNN2KCNN3KCNN1LMNA | |
| SCHEMBL26956106 | 0.81 | MAOA (0.75) | MAOAHTR2CHTR2BKCNN2KCNN3 | |
| SCHEMBL29515907 | 0.81 | MAOA (0.75) | MAOAHTR2CHTR2BKCNN2KCNN3 | |
| SCHEMBL26956109 | 0.77 | KCNN2 (0.59) | KCNN2KCNN3KCNN1LMNAKDM4E | |
| SCHEMBL12862817 | 0.76 | MAOA (0.48) | MAOAHTR2CHTR2BKCNN2KCNN3 | |
| Hydrochloric Acid SCHEMBL10701523 | 0.74 | MAOA (0.62) | MAOAHTR2CHTR2BHTR2AMAPK1 | |
| SCHEMBL1096839 | 0.73 | HTR2C (0.58) | MAOAHTR2CHTR2BHTR2ACYP2D6 | |
| SCHEMBL1901665 | 0.73 | HTR2C (0.58) | MAOAHTR2CHTR2BHTR2ACYP2D6 | |
| SCHEMBL1096838 | 0.73 | HTR2C (0.58) | MAOAHTR2CHTR2BHTR2ACYP2D6 | |
| SCHEMBL10703656 | 0.72 | MAOA (0.65) | MAOAHTR2CHTR2BHTR2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240362-A1 | DIAMINOPYRIMIDINE CARBOXAMIDE INHIBITORS OF HPK1 | Merck Sharp & Dohme LLC (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022098809-A1 | DIAMINOPYRIMIDINE CARBOXAMIDE INHIBITORS OF HPK1 | MERCK SHARP & DOHME CORP. (US) | 2022-05-12 | — | — | WO | disclosed |