Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.75 |
| ▸ | HTR2C | P28335 | 5/20 | 0.54 |
| ▸ | HTR2B | P41595 | 5/20 | 0.54 |
| ▸ | HTR2A | P28223 | 4/20 | 0.54 |
| ▸ | KCNN2 | Q9H2S1 | 4/20 | 0.50 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.50 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26956106 | 1.00 | MAOA (0.75) | MAOAHTR2CHTR2BHTR2AKCNN2 | |
| SCHEMBL1760713 | 0.87 | MAOA (0.97) | MAOAKCNN2KCNN3KCNN1SMN1; SMN2 | |
| SCHEMBL19888927 | 0.87 | MAOA (0.97) | MAOAKCNN2KCNN3KCNN1SMN1; SMN2 | |
| SCHEMBL29382740 | 0.87 | MAOA (0.97) | MAOAKCNN2KCNN3KCNN1SMN1; SMN2 | |
| SCHEMBL8032032 | 0.84 | MAOA (0.64) | MAOAHTR2CHTR2AKCNN2KCNN3 | |
| SCHEMBL18256759 | 0.83 | MAOA (0.77) | MAOAKCNN2KCNN3KCNN1SMN1; SMN2 | |
| SCHEMBL24039929 | 0.82 | MAOA (0.75) | MAOAKCNN2KCNN3KCNN1SMN1; SMN2 | |
| SCHEMBL14739491 | 0.82 | MAOA (0.86) | MAOAMAPK1 | |
| SCHEMBL27156518 | 0.82 | MAOA (0.75) | MAOAKCNN2KCNN3KCNN1SMN1; SMN2 | |
| SCHEMBL29526418 | 0.81 | MAOA (0.54) | MAOAHTR2CHTR2BHTR2AKCNN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230399341-A1 | 7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1 | MERCK SHARP & DOHME LLC (US) | 2023-12-14 | — | — | US | disclosed |
| EP-4240363-A1 | 7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1 | Merck Sharp & Dohme LLC (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022098806-A1 | 7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1 | MERCK SHARP & DOHME CORP. (US) | 2022-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230399341-A1 | 7-PHENYL SUBSTITUTED 2-AMINOQUINAZOLINE INHIBITORS OF HPK1 | PHKG1, PDXK, HIPK1 | MAOA 3869/4885HTR2C 3689/4885HTR2B 3926/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.