Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 11/20 | 0.37 |
| ▸ | P2RX2 | Q9UBL9 | 11/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29527165 | 0.82 | MAPT (0.35) | P2RX3P2RX2MAPTRORCCYP1A2 | |
| SCHEMBL14853414 | 0.74 | CCNB2 (0.32) | — | |
| SCHEMBL29527631 | 0.74 | RORC (0.53) | P2RX3P2RX2MAPTRORCTHRB | |
| SCHEMBL22959151 | 0.74 | RORC (0.53) | P2RX3P2RX2MAPTRORCTHRB | |
| SCHEMBL23259886 | 0.70 | MAPT (0.30) | MAPT | |
| SCHEMBL29526616 | 0.69 | MAPT (0.33) | MAPTRORCCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL26420740 | 0.69 | MAPT (0.48) | P2RX3P2RX2MAPTSCN9ANPC1 | |
| SCHEMBL22632483 | 0.67 | THRB (0.37) | P2RX3P2RX2MAPTRORCTHRB | |
| SCHEMBL29414800 | 0.67 | THRB (0.37) | P2RX3P2RX2MAPTRORCTHRB | |
| SCHEMBL24449964 | 0.67 | RORC (0.46) | P2RX3P2RX2MAPTRORCSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240730-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| CN-116710443-A | 2-pyridones as thyroid hormone receptor modulators | 阿利戈斯治疗公司 | 2023-09-05 | — | — | CN | disclosed |
| WO-2022099044-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |