Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 13/20 | 0.47 |
| ▸ | THRB | P10828 | 13/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29526603 | 0.93 | THRB (0.48) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL29527489 | 0.88 | THRB (0.60) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL29526659 | 0.84 | THRB (0.46) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL29526823 | 0.83 | THRB (0.47) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL29527302 | 0.83 | THRB (0.43) | THRATHRBCYP2C9SMN1; SMN2NPC1 | |
| SCHEMBL29632801 | 0.81 | THRB (0.64) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL29527126 | 0.81 | THRA (0.55) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL29526862 | 0.80 | THRB (0.55) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL24408059 | 0.80 | THRB (0.53) | THRATHRBCYP2C9CYP2C8UGT1A1 | |
| SCHEMBL29527347 | 0.78 | THRA (0.56) | THRATHRBCYP2C9CYP2C8UGT1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240730-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022099044-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |