Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 16/20 | 0.39 |
| ▸ | THRA | P10827 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 4/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29527283 | 0.89 | THRB (0.48) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29526790 | 0.84 | THRB (0.35) | THRBTHRANPBWR1MCHR1 | |
| SCHEMBL29527069 | 0.81 | THRB (0.37) | THRBTHRANPBWR1MCHR1 | |
| SCHEMBL29527246 | 0.81 | THRB (0.37) | THRBTHRANPBWR1MCHR1 | |
| SCHEMBL29526835 | 0.80 | THRB (0.36) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29527155 | 0.79 | THRB (0.34) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL24407977 | 0.79 | THRB (0.55) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL29527253 | 0.79 | RORC (0.32) | THRBTHRANPBWR1 | |
| SCHEMBL29526890 | 0.78 | THRB (0.49) | THRBTHRACYP2C9UGT1A1ABCG2 | |
| SCHEMBL28865196 | 0.76 | THRB (0.47) | THRBTHRACYP2C9UGT1A1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240730-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | claimed |
| WO-2022099044-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | claimed |
| EP-4240730-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | Aligos Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022099044-A1 | 2-PYRIDONES AS THYROID HORMONE RECEPTOR MODULATORS | ALIGOS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |