Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 18/20 | 0.51 |
| ▸ | MET | P08581 | 13/20 | 0.51 |
| ▸ | MERTK | Q12866 | 8/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | HCK | P08631 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22749975 | 1.00 | AXL (0.51) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL22749991 | 0.93 | AXL (0.50) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL29529324 | 0.93 | AXL (0.50) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL21200779 | 0.90 | AXL (0.56) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL30616283 | 0.90 | AXL (0.56) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL29529447 | 0.87 | AXL (0.50) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL21201097 | 0.87 | AXL (0.50) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL372017 | 0.86 | MET (0.66) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL29883010 | 0.86 | MET (0.66) | AXLMETMERTKAURKARIPK2 | |
| SCHEMBL21201265 | 0.84 | AXL (0.54) | AXLMETMERTKAURKARIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3980404-A1 | COMPOUNDS FOR THE TREATMENT OF KINASE-DEPENDENT DISORDERS | Exelixis, Inc. (US) | 2022-04-13 | — | — | EP | disclosed |