SCHEMBL2952972

SCHEMBL2952972

COc1ccc(Nc2ccc(-c3ccc(-c4ccc(Nc5ccc(OC)cc5C)cc4)cc3)cc2)c(C)c1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.75
ADRA2A P08913 1/20 0.53
ADRA2C P18825 1/20 0.53
ADRA1D P25100 1/20 0.53
ADRA1A P35348 1/20 0.53
ADRA1B P35368 1/20 0.53
MAPT P10636 2/20 0.50
KDM4E B2RXH2 1/20 0.50
NPC1 O15118 1/20 0.50
THRB P10828 1/20 0.50
MAPK1 P28482 1/20 0.50
RECQL P46063 1/20 0.50
RAB9A P51151 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
TDP1 Q9NUW8 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
AKR1C3 P42330 3/20 0.48
AKR1C2 P52895 3/20 0.48
POLB P06746 2/20 0.48
RAD52 P43351 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10655147 0.94 GAA (0.82) GAAADRA2AADRA2CADRA1DADRA1A
SCHEMBL25634740 0.93 GAA (0.80) GAAADRA2AADRA2CADRA1DADRA1A
SCHEMBL21131527 0.90 GAA (0.61) GAAMAPTKDM4ENPC1THRB
SCHEMBL6999192 0.89 GAA (0.75) GAAADRA2AADRA2CADRA1DADRA1A
SCHEMBL7002502 0.86 GAA (0.71) GAAADRA2AADRA2CADRA1DADRA1A
SCHEMBL9479715 0.86 GAA (0.93) GAAADRA2AADRA2CADRA1DADRA1A
SCHEMBL502786 0.86 GAA (1.00) GAAADRA2AADRA2CADRA1DADRA1A
SCHEMBL186440 0.82 GAA (0.65) GAAADRA2AADRA2CADRA1DADRA1A
SCHEMBL25633969 0.82 GAA (0.65) GAAADRA2AADRA2CADRA1DADRA1A
SCHEMBL9629642 0.82 GAA (0.65) GAAMAPTKDM4ENPC1THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2518046-B1 P-Terphenyl compound and electrophotographic photoconductor using the same HODOGAYA CHEMICAL CO LTD (JP) 2014-12-10 EP disclosed
EP-2759531-A1 P-Terphenyl compound and electrophotographic photoconductor using the same Hodogaya Chemical Co., Ltd. (JP) 2014-07-30 EP disclosed
EP-2518046-A1 P-Terphenyl compound and electrophotographic photoconductor using the same Hodogaya Chemical Co., Ltd. (JP) 2012-10-31 EP disclosed
US-7799492-B2 P-terphenyl compound and photosensitive body for electrophotography using such compound HODOGAYA CHEMICAL CO., LTD. (JP) 2010-09-21 US disclosed
US-7759030-B2 P-terphenyl compound and photosensitive body for electrophotography using such compound HODOGAYA CHEMICAL CO., LTD. (JP) 2010-07-20 US disclosed
US-20100015542-A1 N,N,N',N'- phenyl substituted diamino p-terphenyl; improved solubility in an organic solvent, charge transporting agent, electrophotographic photoconductor; N,N'-bisindane-5-yl-N,N'-di-p-tolyl-4,4''-diamino-p-terphenyl HODOGAYA CHEMICAL CO., LTD. (JP) 2010-01-21 US disclosed
US-20080076050-A1 P-Terphenyl Compound And Photosensitve Body For Electrophotography Using Such Compound HODOGAYA CHEMICAL CO., LTD. (JP) 2008-03-27 US disclosed
EP-1752441-A1 P-TERPHENYL COMPOUND AND PHOTOSENSITIVE BODY FOR ELECTROPHOTOGRAPHY USING SUCH COMPOUND Hodogaya Chemical Co., Ltd. (JP) 2007-02-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080076050-A1 P-Terphenyl Compound And Photosensitve Body For Electrophotography Using Such Compound SLCO2A1, SLCO2B1, SLC26A4 GAA 3140/4885ADRA2A 3566/4885ADRA2C 3359/4885
US-20100015542-A1 N,N,N',N'- phenyl substituted diamino p-terphenyl; improved solubility in an organic solvent, charge transporting agent, electrophotographic photoconductor; N,N'-bisindane-5-yl-N,N'-di-p-tolyl-4,4''-diamino-p-terphenyl SLC43A3, SLC29A2, SLCO2A1 GAA 2965/4885ADRA2A 2324/4885ADRA2C 3180/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.