Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | PNP | P00491 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15740944 | 1.00 | BRD4 (0.38) | BRD4CREBBPDGAT1FGFR1FGFR4 | |
| SCHEMBL27596810 | 0.81 | BRD4 (0.38) | BRD4CREBBPDGAT1FGFR1FGFR4 | |
| SCHEMBL30280098 | 0.81 | BRD4 (0.36) | BRD4CREBBPDGAT1PNPUSP2 | |
| SCHEMBL30280087 | 0.81 | BRD4 (0.38) | BRD4CREBBPDGAT1PNPUSP2 | |
| SCHEMBL12791523 | 0.80 | DGAT1 (0.39) | BRD4CREBBPDGAT1MAPT | |
| SCHEMBL15118602 | 0.80 | BRD4 (0.39) | BRD4CREBBPDGAT1PNPUSP2 | |
| SCHEMBL25330377 | 0.78 | PRPS1 (0.38) | BRD4CREBBPDGAT1MAPTPDE10A | |
| SCHEMBL29530935 | 0.78 | PRPS1 (0.38) | BRD4CREBBPDGAT1MAPTPDE10A | |
| SCHEMBL20455636 | 0.78 | DGAT1 (0.36) | DGAT1MAPTPDE10A | |
| SCHEMBL29513954 | 0.78 | DGAT1 (0.36) | DGAT1MAPTPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4408837-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE IL-17 INHIBITOR COMPOUNDS | JANSSEN Pharmaceutica NV (BE) | 2024-08-07 | — | — | EP | disclosed |
| CN-117586253-A | Protein degradation agent, preparation method thereof and application thereof in pharmacy | 上海汇伦医药股份有限公司 | 2024-02-23 | — | — | CN | disclosed |
| CN-116940354-A | Fused heteroaryl compounds and their use as CaMKII inhibitors | 卡都瑞恩医药股份有限公司 | 2023-10-24 | — | — | CN | disclosed |
| EP-4216948-A1 | FUSED HETEROARYL COMPOUNDS AND THEIR USE AS CAMKII INHIBITORS | Cardurion Pharmaceuticals, Inc. (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2023049885-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE IL-17 INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2023-03-30 | — | — | WO | disclosed |
| WO-2022067082-A1 | FUSED HETEROARYL COMPOUNDS AND THEIR USE AS CAMKII INHIBITORS | CARDURION PHARMACEUTICALS, LLC (US) | 2022-03-31 | — | — | WO | disclosed |