Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 2/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 2/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ACP1 | P24666 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28593997 | 0.86 | LMNA (0.61) | NCF1HSP90AB1APPLTA4HLMNA | |
| SCHEMBL28203119 | 0.85 | NCF1 (0.53) | NCF1APPLMNAADORA2AL3MBTL1 | |
| SCHEMBL28521021 | 0.81 | ITGB1 (0.46) | LTA4HLMNACYP1A2CYP2D6MAPT | |
| SCHEMBL28513286 | 0.81 | ITGB1 (0.46) | LTA4HLMNACYP1A2CYP2D6MAPT | |
| SCHEMBL27697519 | 0.81 | KMT2A (0.53) | NCF1LMNAALDH1A1ATMKDM4E | |
| SCHEMBL28510041 | 0.80 | NCF1 (0.47) | NCF1ADORA2ACYP1A2ALDH1A1KDM4E | |
| SCHEMBL29532060 | 0.79 | APP (0.50) | NCF1HSP90AB1APPLTA4HADORA2A | |
| SCHEMBL509565 | 0.79 | APP (0.50) | NCF1HSP90AB1APPLTA4HADORA2A | |
| SCHEMBL21847406 | 0.77 | HSP90AB1 (0.55) | NCF1HSP90AB1APPLTA4HLMNA | |
| SCHEMBL30842220 | 0.77 | HSP90AB1 (0.55) | NCF1HSP90AB1APPLTA4HLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228624-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 Therapeutics, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081927-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |