Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 5/20 | 0.50 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.50 |
| ▸ | CMA1 | P23946 | 2/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 7/20 | 0.45 |
| ▸ | CDK1 | P06493 | 7/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.45 |
| ▸ | GSK3B | P49841 | 7/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.45 |
| ▸ | TDP2 | O95551 | 3/20 | 0.42 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24317852 | 1.00 | AHR (0.50) | AHRPDK2CMA1CCNB2CDK1 | |
| SCHEMBL24317908 | 0.75 | CYP1B1 (0.39) | CCNB2CDK1CCNB1GSK3BCDK5 | |
| SCHEMBL29532897 | 0.75 | CYP1B1 (0.39) | CCNB2CDK1CCNB1GSK3BCDK5 | |
| SCHEMBL30736009 | 0.73 | AHR (0.64) | AHRPDK2CMA1TDP2EIF2AK2 | |
| SCHEMBL4199395 | 0.73 | AHR (0.64) | AHRPDK2CMA1TDP2EIF2AK2 | |
| SCHEMBL8482582 | 0.72 | KDR (0.48) | CDK5CDK5R1KDRKDM4EMEN1 | |
| SCHEMBL29822885 | 0.72 | ALDH1A1 (0.55) | KDM4EMEN1ALDH1A1CYP1A2KMT2A | |
| SCHEMBL29532065 | 0.72 | KDR (0.48) | CDK5CDK5R1KDRKDM4EMEN1 | |
| SCHEMBL3583801 | 0.72 | ALDH1A1 (0.55) | KDM4EMEN1ALDH1A1CYP1A2KMT2A | |
| SCHEMBL30517035 | 0.72 | ALDH1A1 (0.55) | KDM4EMEN1ALDH1A1CYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118451068-A | Tri-fused ring derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2024-08-06 | — | — | CN | disclosed |
| CN-116723839-A | Tricyclic heterobifunctional compounds for degrading target proteins | C4医药公司 | 2023-09-08 | — | — | CN | disclosed |
| EP-4228624-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 Therapeutics, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081927-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |