Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 13/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24317908 | 1.00 | CYP1B1 (0.39) | CYP1B1PARP1S1PR2TP53MAPK1 | |
| SCHEMBL7118963 | 0.78 | CDK5 (0.54) | PARP1ALDH1A1POLBKDM4EMEN1 | |
| SCHEMBL29532065 | 0.78 | KDR (0.48) | CYP1B1PARP1ALDH1A1POLBRXFP1 | |
| SCHEMBL8482582 | 0.78 | KDR (0.48) | CYP1B1PARP1ALDH1A1POLBRXFP1 | |
| SCHEMBL29532763 | 0.75 | AHR (0.50) | TP53MAPK1ALDH1A1KDM4EMEN1 | |
| SCHEMBL24317852 | 0.75 | AHR (0.50) | TP53MAPK1ALDH1A1KDM4EMEN1 | |
| SCHEMBL24317408 | 0.74 | CYP1B1 (0.38) | CYP1B1PARP1S1PR2TP53MAPK1 | |
| SCHEMBL24317400 | 0.74 | CYP1B1 (0.35) | CYP1B1PARP1S1PR2TP53MAPK1 | |
| SCHEMBL29532711 | 0.74 | CYP1B1 (0.38) | CYP1B1PARP1S1PR2TP53MAPK1 | |
| SCHEMBL4199390 | 0.70 | RAD52 (0.52) | CYP1B1PARP1MAPK1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228624-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 Therapeutics, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081927-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |