Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 3/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 3/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.33 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24317499 | 1.00 | KMT2A (0.38) | KMT2APARP1TGM2SIRT2SIRT1 | |
| Pyridine SCHEMBL28009697 | 0.75 | PARP1 (0.47) | KMT2APARP1CES1MAPTALDH1A1 | |
| SCHEMBL11318564 | 0.75 | KMT2A (0.45) | KMT2APARP1CES1MAPTALDH1A1 | |
| SCHEMBL7936537 | 0.75 | RAD52 (0.44) | KMT2APARP1CES1MAPTALDH1A1 | |
| SCHEMBL24317500 | 0.75 | CDK2 (0.44) | KMT2APARP1CES1ATG4BMAPT | |
| SCHEMBL10905704 | 0.73 | KMT2A (0.40) | KMT2APARP1CES1ATG4BMAPT | |
| SCHEMBL10865297 | 0.72 | KMT2A (0.42) | KMT2APARP1CES1ATG4BMAPT | |
| SCHEMBL24317498 | 0.71 | MAPT (0.43) | KMT2APARP1MAPTALDH1A1HTT | |
| SCHEMBL29532490 | 0.71 | MAPT (0.43) | KMT2APARP1MAPTALDH1A1HTT | |
| SCHEMBL11838515 | 0.71 | KMT2A (0.38) | KMT2APARP1CES1ATG4BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228624-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 Therapeutics, Inc. (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022081927-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |