SCHEMBL295348

SCHEMBL295348

Cc1cccc(CN(F)F)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 2/20 0.50
IDO1 P14902 2/20 0.48
ACHE P22303 2/20 0.46
CYP2D6 P10635 2/20 0.44
CYP2C9 P11712 2/20 0.44
CYP2C19 P33261 2/20 0.44
RECQL P46063 1/20 0.44
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
MAPT P10636 1/20 0.42
HTT P42858 1/20 0.42
SLC6A2 P23975 1/20 0.42
SLC6A4 P31645 1/20 0.42
SLC6A3 Q01959 1/20 0.42
HRH3 Q9Y5N1 1/20 0.42
HSP90AA1 P07900 1/20 0.41
TAS2R14 Q9NYV8 1/20 0.41
MAOB P27338 1/20 0.41
ALDH1A1 P00352 1/20 0.40
CYP11B1 P15538 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12857 0.80 ALDH1A1 (0.56) TAAR1IDO1ACHECYP2D6CYP2C9
SCHEMBL12124993 0.79 CYP2D6 (0.53) TAAR1IDO1ACHECYP2D6CYP2C9
SCHEMBL10778632 0.78 TAAR1 (0.50) TAAR1IDO1ACHECYP2D6CYP2C9
SCHEMBL30698368 0.78 TAAR1 (0.50) TAAR1IDO1ACHECYP2D6CYP2C9
SCHEMBL24927879 0.77 AOC3 (0.59) TAAR1IDO1ACHECYP2D6CYP2C9
SCHEMBL12772089 0.77 TAS2R14 (0.50) TAAR1IDO1CYP2D6CYP2C9CYP2C19
SCHEMBL12772084 0.77 TAAR1 (0.48) TAAR1IDO1ACHECYP2D6CYP2C9
SCHEMBL24758551 0.77 TAAR1 (0.48) TAAR1IDO1ACHECYP2D6CYP2C9
SCHEMBL19422033 0.77 TAAR1 (0.48) TAAR1IDO1ACHECYP2D6CYP2C9
Hydrochloric Acid SCHEMBL28584835 0.75 IDO1 (0.48) TAAR1IDO1ACHECYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2157078-B1 Fluorine compound and fluorinating agent comprising the compound MITSUBISHI GAS CHEMICAL CO (JP) 2012-03-14 EP disclosed
EP-2157078-A1 Fluorine compound and fluorinating agent comprising the compound Mitsubishi Gas Chemical Company, Inc. (JP) 2010-02-24 EP disclosed