Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 2/20 | 0.43 |
| ▸ | DTYMK | P23919 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5472801 | 1.00 | GPR119 (0.51) | GPR119OPRD1OPRK1POLBJAK2 | |
| SCHEMBL13059786 | 0.91 | GPR119 (0.51) | GPR119OPRD1OPRK1POLBJAK2 | |
| SCHEMBL3325436 | 0.89 | GPR119 (0.50) | GPR119OPRD1OPRK1POLBJAK2 | |
| SCHEMBL20493552 | 0.86 | OPRD1 (0.52) | GPR119OPRD1OPRK1POLBJAK2 | |
| SCHEMBL30227070 | 0.86 | OPRD1 (0.52) | GPR119OPRD1OPRK1POLBJAK2 | |
| SCHEMBL1181843 | 0.84 | GPR119 (0.54) | GPR119OPRD1OPRK1POLBJAK2 | |
| SCHEMBL6888743 | 0.83 | GPR119 (0.53) | GPR119OPRD1OPRK1POLBJAK2 | |
| SCHEMBL2224318 | 0.83 | GPR119 (0.53) | GPR119OPRD1OPRK1POLBJAK2 | |
| SCHEMBL11963144 | 0.83 | JAK2 (0.43) | GPR119OPRD1OPRK1POLBJAK2 | |
| SCHEMBL5472913 | 0.82 | GPR119 (0.52) | GPR119OPRD1OPRK1POLBJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4192458-A1 | COMPOUNDS FOR TARGETED DEGRADATION OF RET | C4 Therapeutics, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |
| WO-2022032026-A1 | COMPOUNDS FOR TARGETED DEGRADATION OF RET | C4 THERAPEUTICS, INC. (US) | 2022-02-10 | — | — | WO | disclosed |