Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL10428649 | 0.89 | SLC7A5 (0.41) | SLC7A5 | |
| Histidine SCHEMBL10428650 | 0.89 | SLC7A5 (0.41) | SLC7A5 | |
| Histidine SCHEMBL9551452 | 0.88 | SLC7A5 (0.33) | SLC7A5 | |
| Histidine SCHEMBL29225848 | 0.86 | SLC7A5 (0.37) | SLC7A5 | |
| Histidine SCHEMBL23632728 | 0.86 | SLC7A5 (0.37) | SLC7A5 | |
| Histidine SCHEMBL245022 | 0.85 | SLC7A5 (0.45) | SLC7A5 | |
| Histidine SCHEMBL21638967 | 0.85 | SLC7A5 (0.45) | SLC7A5 | |
| Histidine SCHEMBL2976301 | 0.85 | SLC7A5 (0.36) | SLC7A5 | |
| Histidine SCHEMBL2976304 | 0.85 | SLC7A5 (0.36) | SLC7A5 | |
| Histidine SCHEMBL21774926 | 0.84 | SLC7A5 (0.46) | SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1445325-B1 | PROCESSES FOR PRODUCING ISOMALTOSE AND ISOMALTITOL AND USE THEREOF | HAYASHIBARA BIOCHEM LAB (JP) | 2010-05-26 | — | — | EP | claimed |
| EP-2463378-B1 | Alpha isomaltosylglucosaccharide synthase, process for producing the same and use thereof | HAYASHIBARA CO (JP) | 2015-12-23 | — | — | EP | disclosed |
| EP-2463378-A1 | Alpha isomaltosylglucosaccharide synthase, process for producing the same and use thereof | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2012-06-13 | — | — | EP | disclosed |
| EP-1229112-B1 | ALPHA-ISOMALTOSYLGLUCOSACCHARIDE SYNTHASE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | HAYASHIBARA BIOCHEM LAB (JP) | 2012-03-14 | — | — | EP | disclosed |
| US-7811797-B2 | α-isomaltosylglucosaccharide-forming enzyme, process and uses of the same | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2010-10-12 | — | — | US | disclosed |
| EP-1445325-B1 | PROCESSES FOR PRODUCING ISOMALTOSE AND ISOMALTITOL AND USE THEREOF | HAYASHIBARA BIOCHEM LAB (JP) | 2010-05-26 | — | — | EP | disclosed |
| US-7718404-B2 | α-isomaltosylglucosaccharide-forming enzyme, process and uses of the same | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2010-05-18 | — | — | US | disclosed |
| US-7592160-B2 | Processes for producing isomaltose and isomaltitol and use thereof | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2009-09-22 | — | — | US | disclosed |
| US-20080032350-A1 | Alpha-isomaltosylglucosaccharide-forming enzyme, process and uses of the same | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2008-02-07 | — | — | US | disclosed |
| US-20080003651-A1 | alpha-isomaltosylglucosaccharide-forming enzyme, process and uses of the same | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2008-01-03 | — | — | US | disclosed |
| US-7241606-B2 | α-Isomaltosylglucosaccharide synthase, process for producing the same and use thereof | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2007-07-10 | — | — | US | disclosed |
| US-20060240531-A1 | Processes for producing isomaltose and isomaltitol and use thereof | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2006-10-26 | — | — | US | disclosed |
| EP-1445325-A1 | PROCESSES FOR PRODUCING ISOMALTOSE AND ISOMALTITOL AND USE THEREOF | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) | 2004-08-11 | — | — | EP | disclosed |
| US-20030194762-A1 | Alpha-Isomaltosylglucosaccharide synthase, process for producing the same and use thereof | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2003-10-16 | — | — | US | disclosed |
| EP-1229112-A1 | ALPHA-ISOMALTOSYLGLUCOSACCHARIDE SYNTHASE, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo (JP) | 2002-08-07 | — | — | EP | disclosed |