Histidine

Histidine

SCHEMBL245022

CC(C)C[C@H](N)C(=O)O.CC(C)[C@H](N)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 4/20 0.45
SLC1A3 P43003 3/20 0.38
SLC1A2 P43004 3/20 0.38
CYP3A4 P08684 1/20 0.36
SLC1A1 P43005 2/20 0.36
CYP1A2 P05177 1/20 0.35
ANPEP P15144 1/20 0.34
RNPEP Q9H4A4 1/20 0.34
DNPEP Q9ULA0 1/20 0.34
GRIA1 P42261 5/20 0.34
GRIA2 P42262 5/20 0.34
GRIA3 P42263 5/20 0.34
GRIA4 P48058 5/20 0.34
LARS1 Q9P2J5 2/20 0.33
ALPI P09923 1/20 0.32
PKM P14618 1/20 0.32
PTGS1 P23219 1/20 0.32
XIAP P98170 1/20 0.32
GRIK1 P39086 3/20 0.32
GRIK2 Q13002 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL21638967 1.00 SLC7A5 (0.45) SLC7A5SLC1A3SLC1A2CYP3A4SLC1A1
Histidine SCHEMBL1537307 0.94 SLC7A5 (0.43) SLC7A5CYP3A4CYP1A2GRIA1GRIA2
Histidine SCHEMBL1061774 0.94 SLC7A5 (0.43) SLC7A5CYP3A4CYP1A2GRIA1GRIA2
Histidine SCHEMBL1061772 0.94 SLC7A5 (0.43) SLC7A5CYP3A4CYP1A2GRIA1GRIA2
Histidine SCHEMBL1537416 0.94 SLC7A5 (0.51) SLC7A5SLC1A3SLC1A2CYP3A4SLC1A1
Histidine SCHEMBL716109 0.94 SLC7A5 (0.51) SLC7A5SLC1A3SLC1A2CYP3A4SLC1A1
Histidine SCHEMBL716108 0.94 SLC7A5 (0.51) SLC7A5SLC1A3SLC1A2CYP3A4SLC1A1
Histidine SCHEMBL28870433 0.92 SLC7A5 (0.50) SLC7A5SLC1A3SLC1A2CYP3A4SLC1A1
Histidine SCHEMBL27486516 0.92 SLC7A5 (0.42) SLC7A5CYP3A4CYP1A2GRIA1GRIA2
Histidine SCHEMBL2126474 0.91 SLC7A5 (0.38) SLC7A5SLC1A3SLC1A2CYP3A4SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220137035-A1 DETECTION OF HEMOGLOBIN A1C (HbA1c) IN BLOOD PROCISEDX INC. (US) 2022-05-05 US disclosed
CN-105431545-B Method for measuring glycated hemoglobin 日立化成诊断系统株式会社 2021-06-18 CN disclosed
EP-3020825-B1 METHOD FOR MEASURING GLYCATED HEMOGLOBIN HITACHI CHEMICAL DIAGNOSTICS SYSTEMS CO LTD (JP) 2020-02-19 EP disclosed
EP-3020810-B1 GLYCATED HEXAPEPTIDE OXIDASE AND USE THEREOF KYOWA MEDEX CO LTD (JP) 2019-04-10 EP disclosed
US-10006923-B2 Method for measuring glycated hemoglobin KYOWA MEDEX CO., LTD. (JP) 2018-06-26 US disclosed
US-9944970-B2 Glycated hexapeptide oxidase and use thereof KYOWA MEDEX CO., LTD. (JP) 2018-04-17 US disclosed
EP-2357228-B1 NOVEL FRUCTOSYL PEPTIDE OXIDASE KYOWA MEDEX CO LTD (JP) 2017-05-10 EP disclosed
US-20160138073-A1 GLYCATED HEXAPEPTIDE OXIDASE AND USE THEREOF CANON MEDICAL DIAGNOSTICS CORPORATION (JP) 2016-05-19 US disclosed
EP-3020810-A1 GLYCATED HEXAPEPTIDE OXIDASE AND USE THEREOF Kyowa Medex Co., Ltd. (JP) 2016-05-18 EP disclosed
EP-3020825-A1 METHOD FOR MEASURING GLYCATED HEMOGLOBIN Kyowa Medex Co., Ltd. (JP) 2016-05-18 EP disclosed
US-8790905-B2 Fructosyl peptide oxidase KYOWA MEDEX CO., LTD. (JP) 2014-07-29 US disclosed
US-20140057333-A1 NOVEL FRUCTOSYL PEPTIDE OXIDASE KYOWA MEDEX CO., LTD. (JP) 2014-02-27 US disclosed
US-8304249-B2 Fructosyl peptide oxidase KYOWA MEDEX CO., LTD. (JP) 2012-11-06 US disclosed
US-20120003678-A1 NOVEL FRUCTOSYL PEPTIDE OXIDASE KYOWA MEDEX CO., LTD. (JP) 2012-01-05 US disclosed
EP-2357228-A1 NOVEL FRUCTOSYL PEPTIDE OXIDASE Kyowa Medex CO., LTD. (JP) 2011-08-17 EP disclosed
EP-1548115-B1 FRUCTOSYLAMINE OXIDASE ARKRAY INC (JP) 2009-11-11 EP disclosed
US-7407783-B2 Fructosylamine oxidase ARKRAY, INC. (JP) 2008-08-05 US disclosed
US-20060172367-A1 Fructosylamine oxidase ARKRAY, INC. (JP) 2006-08-03 US disclosed
CN-1701118-A Fructosylamine oxidase ARKRAY INC (JP) 2005-11-23 CN disclosed
EP-1548115-A1 FRUCTOSYLAMINE OXIDASE ARKRAY, Inc. (JP) 2005-06-29 EP disclosed