Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.62 |
| ▸ | MAOA | P21397 | 2/20 | 0.62 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.62 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1993714 | 1.00 | KDM1A (0.62) | KDM1AMAOAKDM1BRCOR1HRH3 | |
| SCHEMBL5583030 | 0.89 | KDM1A (0.67) | KDM1AMAOAKDM1BRCOR1HRH3 | |
| SCHEMBL29536854 | 0.85 | HRH3 (0.55) | KDM1AMAOAKDM1BRCOR1HRH3 | |
| SCHEMBL1987913 | 0.85 | HRH3 (0.55) | KDM1AMAOAKDM1BRCOR1HRH3 | |
| SCHEMBL1994927 | 0.82 | NPC1 (0.51) | NPC1RAB9A | |
| SCHEMBL29536791 | 0.82 | NPC1 (0.51) | NPC1RAB9A | |
| SCHEMBL1991891 | 0.81 | LMNA (0.68) | LMNAMAPTNPC1TP53NFKB1 | |
| SCHEMBL27922223 | 0.81 | HRH3 (0.51) | KDM1AMAOAKDM1BRCOR1HRH3 | |
| SCHEMBL23134213 | 0.81 | LSS (0.60) | — | |
| SCHEMBL8082343 | 0.81 | LSS (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3187490-B1 | SUBSTITUTED BENZAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2022-04-06 | — | — | EP | claimed |