Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | KDM1B | Q8NB78 | 2/20 | 0.47 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27904316 | 0.87 | SLC6A3 (0.47) | LMNAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL502899 | 0.82 | TP53 (0.59) | HRH3LMNAMAPTNPC1RAB9A | |
| SCHEMBL502898 | 0.82 | TP53 (0.59) | HRH3LMNAMAPTNPC1RAB9A | |
| SCHEMBL29536946 | 0.81 | KDM1A (0.62) | HRH3LMNAMAPTNPC1RAB9A | |
| SCHEMBL1993714 | 0.81 | KDM1A (0.62) | HRH3LMNAMAPTNPC1RAB9A | |
| SCHEMBL27594938 | 0.80 | DRD2 (0.48) | — | |
| SCHEMBL29536854 | 0.79 | HRH3 (0.55) | HRH3LMNAMAPTNPC1RAB9A | |
| SCHEMBL1987913 | 0.79 | HRH3 (0.55) | HRH3LMNAMAPTNPC1RAB9A | |
| SCHEMBL14454767 | 0.77 | NAMPT (0.59) | HRH3MAPTTP53 | |
| SCHEMBL28822434 | 0.77 | ALDH1A1 (0.54) | LMNARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103068379-A | Combinations comprising an atypical antipsychotic and a TAAR1 agonist | HOFFMANN LA ROCHE | 2013-04-24 | — | — | CN | disclosed |