Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.41 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.40 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.39 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.39 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.39 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13239748 | 1.00 | MAPK14 (0.57) | MAPK14MAPK8METTRPA1RPS6KA4 | |
| SCHEMBL29537130 | 0.85 | BRD4 (0.45) | MAPK14MET | |
| SCHEMBL25228119 | 0.85 | BRD4 (0.45) | MAPK14MET | |
| SCHEMBL30640268 | 0.84 | MAPK14 (0.41) | MAPK14METMAPK1 | |
| SCHEMBL22139066 | 0.82 | MAPK14 (0.60) | MAPK14MAPK8TRPA1RPS6KA4MAPK9 | |
| SCHEMBL29593402 | 0.82 | MAPK14 (0.52) | MAPK14MAPK8MAPK1 | |
| SCHEMBL14266291 | 0.81 | MAPK14 (0.56) | MAPK14MAPK8TRPA1MAPK9MAPK10 | |
| SCHEMBL6073545 | 0.77 | HPGD (0.40) | MAPK14MAPK1 | |
| SCHEMBL14014098 | 0.76 | MAPK14 (0.70) | MAPK14MAPK8RPS6KA4MAPK9RPS6KA3 | |
| SCHEMBL29830087 | 0.76 | MAPK14 (0.70) | MAPK14MAPK8RPS6KA4MAPK9RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112079830-B | Inhibitor containing fused ring derivative, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-116710453-A | Kinase inhibitors and uses thereof | 璧辰医药技术股份有限公司 | 2023-09-05 | — | — | CN | disclosed |
| EP-4192582-A1 | KINASE INHIBITORS AND USES THEREOF | ABM Therapeutics Corporation (US) | 2023-06-14 | — | — | EP | disclosed |
| CN-115322193-A | EGFR and/or HER2 inhibitors and methods of use | 达纳-法伯癌症研究所股份有限公司 | 2022-11-11 | — | — | CN | disclosed |
| CN-111032655-B | EGFR and/or HER2 inhibitors and methods of use | 达纳-法伯癌症研究所股份有限公司 | 2022-09-02 | — | — | CN | disclosed |
| WO-2022032071-A1 | KINASE INHIBITORS AND USES THEREOF | ABM THERAPEUTICS CORPORATION (US) | 2022-02-10 | — | — | WO | disclosed |