Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 10/20 | 0.46 |
| ▸ | CTSS | P25774 | 9/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | PTPRA | P18433 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18301503 | 0.87 | CTSK (0.47) | ATMCTSKCTSSKCNA5FOLH1 | |
| SCHEMBL19309171 | 0.86 | ATM (0.44) | ATMCTSKCTSSCTSLCTSB | |
| SCHEMBL5586793 | 0.84 | CTSK (0.49) | ATMCTSKCTSSCTSLCTSB | |
| SCHEMBL20845474 | 0.82 | ATM (0.49) | ATMCTSKCTSSCTSLCTSB | |
| SCHEMBL16970726 | 0.82 | ATM (0.49) | ATMCTSKCTSSCTSLCTSB | |
| SCHEMBL14665422 | 0.82 | KCNA5 (0.45) | ATMCTSKCTSSCTSLCTSB | |
| SCHEMBL3676162 | 0.81 | NPC1 (0.63) | ATMCTSKCTSSCTSLCTSB | |
| SCHEMBL12203694 | 0.81 | NPC1 (0.63) | ATMCTSKCTSSCTSLCTSB | |
| SCHEMBL3676166 | 0.81 | NPC1 (0.63) | ATMCTSKCTSSCTSLCTSB | |
| SCHEMBL29401299 | 0.81 | NPC1 (0.63) | ATMCTSKCTSSCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111647036-B | Ocotillol esterified derivatives, preparation method thereof and application thereof in preparing anti-inflammatory drugs | 烟台大学 | 2022-05-13 | — | — | CN | disclosed |
| CN-111647036-A | Ocotillol esterified derivatives, preparation method thereof and application thereof in preparing anti-inflammatory drugs | 烟台大学 | 2020-09-11 | — | — | CN | disclosed |
| CN-101516378-B | Morpholinyl and pyrrolidinyl analogs | SMITHKLINE BEECHAM CORP | 2011-06-15 | — | — | CN | disclosed |
| US-20100256130-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | GOODMAN KRISTA B | 2010-10-07 | — | — | US | disclosed |
| US-7749998-B2 | Morpholinyl and pyrrolidinyl analogs | GLAXOSMITHKLINE LLC (US) | 2010-07-06 | — | — | US | disclosed |
| US-20090275571-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | SMITHKLINE BEECHAM CORPORATION | 2009-11-05 | — | — | US | disclosed |
| CN-101516378-A | Morpholinyl and pyrrolidinyl analogs | SMITHKLINE BEECHAM CORP (US) | 2009-08-26 | — | — | CN | disclosed |
| US-7432258-B2 | Morpholinyl and pyrrolidinyl analogs | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-20080021023-A1 | 4'-[(1R)-1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin- 4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxylic acid; as antagonists of urotensin II, congestive heart failure, stroke, ischemic heart disease (e.g. angina, myocardial ischemia), cardiac arrhythmia, hypertension | GLAXOSMITHKLINE LLC | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256130-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | UTS2R, AVPR2, VIPR2 | ATM 4764/4885CTSK 248/4885CTSS 88/4885 |
| US-20090275571-A1 | MORPHOLINYL AND PYRROLIDINYL ANALOGS | UTS2R, AVPR2, VIPR2 | ATM 4764/4885CTSK 248/4885CTSS 88/4885 |
| US-20080021023-A1 | 4'-[(1R)-1-[[(6,7-dichloro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin- 4-yl)acetyl](methyl)amino]-2-(4-morpholinyl)ethyl]-4-biphenylcarboxylic acid; as antagonists of urotensin II, congestive heart failure, stroke, ischemic heart disease (e.g. angina, myocardial ischemia), cardiac arrhythmia, hypertension | UTS2R, PLAUR, FABP3 | ATM 4795/4885CTSK 981/4885CTSS 636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.