Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1989607 | 1.00 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9ANR3C1TP53 | |
| SCHEMBL1990469 | 0.89 | USP30 (0.49) | SMN1; SMN2NPC1RAB9ANR3C1TP53 | |
| SCHEMBL17514225 | 0.88 | RORC (0.52) | RORCMEN1KMT2ANPSR1 | |
| SCHEMBL31412611 | 0.88 | RORC (0.52) | RORCMEN1KMT2ANPSR1 | |
| SCHEMBL31412569 | 0.88 | RORC (0.52) | RORCMEN1KMT2ANPSR1 | |
| SCHEMBL502898 | 0.81 | TP53 (0.59) | SMN1; SMN2NPC1RAB9ANR3C1TP53 | |
| SCHEMBL502899 | 0.81 | TP53 (0.59) | SMN1; SMN2NPC1RAB9ANR3C1TP53 | |
| SCHEMBL17542185 | 0.81 | MEN1 (0.60) | SMN1; SMN2NPC1RAB9ANR3C1TP53 | |
| SCHEMBL17542065 | 0.80 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9ANR3C1TP53 | |
| SCHEMBL14454767 | 0.78 | NAMPT (0.59) | NR3C1TP53MAPTTHRBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3187490-B1 | SUBSTITUTED BENZAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2022-04-06 | — | — | EP | disclosed |