Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MC4R | P32245 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.47 |
| ▸ | STS | P08842 | 2/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17514225 | 1.00 | RORC (0.52) | RORCMEN1KMT2AMC4RPDE4B | |
| SCHEMBL31412611 | 1.00 | RORC (0.52) | RORCMEN1KMT2AMC4RPDE4B | |
| SCHEMBL31341850 | 0.88 | STS (0.51) | RORCMEN1KMT2AMC4RPDE4B | |
| SCHEMBL1989607 | 0.88 | SMN1; SMN2 (0.48) | RORCMEN1KMT2ANPSR1 | |
| SCHEMBL29538387 | 0.88 | SMN1; SMN2 (0.48) | RORCMEN1KMT2ANPSR1 | |
| SCHEMBL3993928 | 0.86 | RORC (0.55) | RORCMEN1KMT2APDE4BNAMPT | |
| SCHEMBL16070094 | 0.86 | RORC (0.55) | RORCMEN1KMT2APDE4BNAMPT | |
| SCHEMBL1992736 | 0.86 | RORC (0.52) | RORCPDE4BNAMPTKCNK3KCNK9 | |
| SCHEMBL6917693 | 0.86 | RORC (0.52) | RORCPDE4BNAMPTKCNK3KCNK9 | |
| SCHEMBL16032347 | 0.86 | RORC (0.55) | RORCMEN1KMT2APDE4BNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025045746-A1 | PYRAZOLE DERIVATIVES AS SARM1 INHIBITORS USEFUL FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2025-03-06 | — | — | WO | disclosed |