Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SPIN4 | Q56A73 | 1/20 | 0.43 |
| ▸ | SPIN3 | Q5JUX0 | 1/20 | 0.43 |
| ▸ | SPIN2B | Q9BPZ2 | 1/20 | 0.43 |
| ▸ | SPIN1 | Q9Y657 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NCF1 | P14598 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.40 |
| ▸ | DNM2 | P50570 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2948586 | 0.80 | NCF1 (0.55) | L3MBTL1KDM4EHRH3NCF1MEN1 | |
| SCHEMBL1090089 | 0.78 | MRGPRX1 (0.61) | L3MBTL1KDM4EATMMAPK1CTDSP1 | |
| SCHEMBL1089644 | 0.78 | MRGPRX1 (0.61) | L3MBTL1KDM4EATMMAPK1CTDSP1 | |
| SCHEMBL1089641 | 0.78 | MRGPRX1 (0.61) | L3MBTL1KDM4EATMMAPK1CTDSP1 | |
| SCHEMBL2955096 | 0.78 | PARP1 (0.43) | L3MBTL1KDM4EATMMAPK1CTDSP1 | |
| SCHEMBL1089104 | 0.77 | MRGPRX1 (0.63) | L3MBTL1KDM4EATMMAPK1CTDSP1 | |
| SCHEMBL2953196 | 0.72 | NCF1 (0.62) | L3MBTL1KDM4EHPGDHRH3NCF1 | |
| SCHEMBL1090582 | 0.71 | MRGPRX1 (0.59) | L3MBTL1KDM4EATMMAPK1CTDSP1 | |
| SCHEMBL1088747 | 0.71 | MRGPRX1 (0.59) | L3MBTL1KDM4EATMMAPK1CTDSP1 | |
| SCHEMBL1089882 | 0.71 | MRGPRX1 (0.59) | L3MBTL1KDM4EATMMAPK1CTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120156219-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2012-06-21 | — | — | US | disclosed |
| US-20100221259-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-09-02 | — | — | US | disclosed |
| US-7759336-B2 | Nitrogen-containing heterocyclic compounds and medicinal use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-07-20 | — | — | US | disclosed |
| US-20070167459-A1 | Nitrogen-containing heterocyclic compounds and medicinal use thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-07-19 | — | — | US | disclosed |
| EP-1571146-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-09-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100221259-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | CXCR4, CXCL12, CXCR3 | L3MBTL1 2480/4885KDM4E 2001/4885ATM 3194/4885 |
| US-20070167459-A1 | Nitrogen-containing heterocyclic compounds and medicinal use thereof | CXCR4, CXCL12, CXCR3 | L3MBTL1 2480/4885KDM4E 2001/4885ATM 3194/4885 |
| US-20120156219-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | CXCR4, CXCL12, CXCR3 | L3MBTL1 2480/4885KDM4E 2001/4885ATM 3194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.